151238

• Gene Symbol: Prkdc
• Gene Name: protein kinase, DNA activated, catalytic polypeptide
• Gene Aliases: AI326420, AU019811, DNA-PKcs, DNAPDcs, DNAPK, DNPK1, DOXNPH, HYRC1, XRCC7, dxnph, p460, scid, slip
• Chromosome Location: Chr.16: 15637444 - 15842252 on Build GRCm38
• UniGene ID: Mm.71
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Prkdc
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_011159.2	NP_035289.2	57, 58	7780
GenBank mRNA	AB007544.1	-	57, 58	7757
	AB011543.1	-	57, 58	7769
	D87521.1	-	57, 58	7757
	DQ235257.1	-	1, 2	110
	DQ235258.1	-	1, 2	110

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: XM_008768933, XM_003751100.

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase, protein modifying enzyme

Gene Ontology Categories:

Process(es)

telomere maintenance
double-strand break repair via homologous recombination
somitogenesis
negative regulation of protein phosphorylation
B cell lineage commitment
pro-B cell differentiation
T cell lineage commitment
immunoglobulin production
negative regulation of immunoglobulin production
positive regulation of immune system process
DNA repair
double-strand break repair
double-strand break repair via nonhomologous end joining
protein phosphorylation
cellular response to DNA damage stimulus
brain development
heart development
intrinsic apoptotic signaling pathway in response to DNA damage
response to ionizing radiation
response to gamma radiation
phosphorylation
peptidyl-serine phosphorylation
lymphocyte differentiation
protein destabilization
cellular response to insulin stimulus
T cell differentiation in thymus
V(D)J recombination
immunoglobulin V(D)J recombination
T cell receptor V(D)J recombination
ectopic germ cell programmed cell death
regulation of circadian rhythm
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of transcription from RNA polymerase II promoter
positive regulation of fibroblast proliferation
rhythmic process
spleen development
thymus development
positive regulation of developmental growth
signal transduction involved in mitotic G1 DNA damage checkpoint
negative regulation of cellular senescence
negative regulation of response to gamma radiation

Function(s)

nucleotide binding
DNA binding
double-stranded DNA binding
protein kinase activity
protein serine/threonine kinase activity
DNA-dependent protein kinase activity
protein binding
ATP binding
transcription factor binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
phosphotransferase activity, alcohol group as acceptor
enzyme binding
poly(A) RNA binding