152350

• Gene Symbol: Foxp3
• Gene Name: forkhead box P3
• Gene Aliases: JM2, scurfin, sf
• Chromosome Location: Chr.X: 7579676 - 7595243 on Build GRCm38
• UniGene ID: Mm.182291
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Foxp3
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001199347.1	NP_001186276.1	14	2188
	NM_001199348.1	NP_001186277.1	13	2046
	NM_054039.2	NP_473380.1	13	2121
GenBank mRNA	AF277991.1	-	13	2046
	AF277992.1	-	13	2104
	AK157447.1	-	14	2189
	BC132333.1	-	12	1892	40130610
	BC132335.1	-	12	1892	40130612
	DQ387959.1	-	14	2188

More Information

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
B cell homeostasis
cytokine production
myeloid cell homeostasis
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment
T cell mediated immunity
tolerance induction
tolerance induction to self antigen
regulation of immunoglobulin production
positive regulation of T cell tolerance induction
regulation of T cell anergy
positive regulation of T cell anergy
negative regulation of chronic inflammatory response
negative regulation of T cell cytokine production
positive regulation of peripheral T cell tolerance induction
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
negative regulation of cell proliferation
anatomical structure morphogenesis
positive regulation of gene expression
negative regulation of histone deacetylation
negative regulation of NF-kappaB transcription factor activity
negative regulation of interferon-gamma production
negative regulation of interleukin-10 production
negative regulation of interleukin-17 production
negative regulation of interleukin-2 production
negative regulation of interleukin-4 production
negative regulation of interleukin-5 production
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
positive regulation of interleukin-4 production
negative regulation of CREB transcription factor activity
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
positive regulation of transforming growth factor beta1 production
positive regulation of immature T cell proliferation in thymus
positive regulation of histone acetylation
negative regulation of histone acetylation
negative regulation of cytokine biosynthetic process
T cell activation
negative regulation of T cell proliferation
negative regulation of sequence-specific DNA binding transcription factor activity
regulatory T cell differentiation
negative regulation of interferon-gamma biosynthetic process
negative regulation of interleukin-2 biosynthetic process
positive regulation of regulatory T cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of isotype switching to IgE isotypes
regulation of isotype switching to IgG isotypes
negative regulation of lymphocyte proliferation
negative regulation of cytokine secretion
negative regulation of inflammatory response
negative regulation of immune response
T cell receptor signaling pathway
negative regulation of T-helper 17 cell differentiation

Function(s)

core promoter binding
nucleic acid binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription corepressor activity
protein binding
histone acetyltransferase binding
protein homodimerization activity
histone deacetylase binding
sequence-specific DNA binding
metal ion binding
NFAT protein binding