15256

• Gene Symbol: ARHGEF2
• Gene Name: Rho/Rac guanine nucleotide exchange factor 2
• Gene Aliases: GEF, GEF-H1, GEFH1, LFP40, P40
• Chromosome Location: Chr.1: 155946839 - 155991263 on Build GRCh38
• UniGene ID: Hs.743352
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: ARHGEF2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001162383.1	NP_001155855.1	3, 4	390
	NM_001162384.1	NP_001155856.1	3, 4	390
	NM_004723.3	NP_004714.2	3, 4	318
	XM_005245587.2	XP_005245644.1	3, 4	443
	XM_005245588.2	XP_005245645.1	3, 4	443
	XM_005245589.4	XP_005245646.1	3, 4	596
	XM_005245590.3	XP_005245647.1	3, 4	318
	XM_005245591.3	XP_005245648.1	4, 5	434
	XM_005245592.2	XP_005245649.1	3, 4	587
	XM_005245593.4	XP_005245650.1	3, 4	318
	XM_005245594.2	XP_005245651.1	3, 4	1304
	XM_006711622.3	XP_006711685.1	3, 4	1581
	XM_011510136.2	XP_011508438.2	7, 8	1002
	XM_011510137.2	XP_011508439.2	7, 8	1002
	XM_011510139.2	XP_011508441.1	7, 8	1002
	XM_011510141.2	XP_011508443.1	3, 4	1120
	XM_017002794.1	XP_016858283.1	7, 8	1002
	XM_017002795.1	XP_016858284.1	3, 4	337
	XM_017002796.1	XP_016858285.1	3, 4	1581
	XM_017002797.1	XP_016858286.1	3, 4	321
GenBank mRNA	AB014551.3	-	7, 8	661
	AF486838.1	-	3, 4	272
	AK295924.1	-	3, 4	587
	AK304548.1	-	6, 7	727
	AL512715.1	-	3, 4	303
	BC020567.1	-	3, 4	372	4157775
	BT007407.1	-	2, 3	191
	CN388788.1	-	3, 4	392

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001012079, XM_006232643, XM_006232648, XM_006232652, XM_008761152, and others.
This siRNA also targets the following transcripts in Mouse: NM_001198912, NM_001198911, NM_008487, NM_001198913, AF177032, and others.

Gene Ontology Categories:

Process(es)

establishment of mitotic spindle orientation
cell morphogenesis
intracellular protein transport
actin filament organization
negative regulation of microtubule depolymerization
mitotic nuclear division
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
regulation of Rho protein signal transduction
intracellular signal transduction
regulation of cell proliferation
positive regulation of apoptotic process
positive regulation of GTPase activity
innate immune response
positive regulation of transcription from RNA polymerase II promoter
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of neurogenesis
regulation of small GTPase mediated signal transduction
positive regulation of NF-kappaB transcription factor activity
cell division
negative regulation of necroptotic process
cellular response to muramyl dipeptide
cellular response to tumor necrosis factor
cellular hyperosmotic response
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

Function(s)

guanyl-nucleotide exchange factor activity
Rho guanyl-nucleotide exchange factor activity
protein binding
microtubule binding
transcription factor binding
zinc ion binding
Rho GTPase binding
Rac guanyl-nucleotide exchange factor activity
Rac GTPase binding