152796

• Gene Symbol: Nod2
• Gene Name: nucleotide-binding oligomerization domain containing 2
• Gene Aliases: ACUG, BLAU, CD, Card15, F830032C23Rik, IBD1, Nlrc2
• Chromosome Location: Chr.8: 88647280 - 88688474 on Build GRCm38
• UniGene ID: Mm.222633
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Nod2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_145857.2	NP_665856.2	13	4238
GenBank mRNA	AF520774.1	-	13	4271
	AK089843.1	-	13	4191
	BC044774.2	-	13	4253

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001106172.

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

innate immune response in mucosa
activation of immune response
cytokine production involved in immune response
cytokine secretion involved in immune response
immune system process
immunoglobulin production involved in immunoglobulin mediated immune response
positive regulation of dendritic cell antigen processing and presentation
negative regulation of T cell mediated immunity
positive regulation of dendritic cell cytokine production
positive regulation of type 2 immune response
negative regulation of inflammatory response to antigenic stimulus
positive regulation of humoral immune response mediated by circulating immunoglobulin
defense response
inflammatory response
positive regulation of antibacterial peptide biosynthetic process
positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
signal transduction
positive regulation of cell proliferation
detection of biotic stimulus
detection of bacterium
maintenance of gastrointestinal epithelium
positive regulation of protein ubiquitination
negative regulation of NF-kappaB transcription factor activity
response to peptidoglycan
response to muramyl dipeptide
response to lipopolysaccharide
detection of muramyl dipeptide
negative regulation of interferon-gamma production
negative regulation of interleukin-12 production
negative regulation of interleukin-18 production
negative regulation of interleukin-2 production
negative regulation of tumor necrosis factor production
positive regulation of interleukin-1 beta production
positive regulation of interleukin-10 production
positive regulation of interleukin-12 production
positive regulation of interleukin-17 production
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
positive regulation of stress-activated MAPK cascade
negative regulation of toll-like receptor 2 signaling pathway
activation of MAPK activity involved in innate immune response
intracellular signal transduction
defense response to bacterium
regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
response to exogenous dsRNA
positive regulation of MAPK cascade
positive regulation of phosphatidylinositol 3-kinase activity
negative regulation of growth of symbiont in host
innate immune response
positive regulation of innate immune response
positive regulation of Notch signaling pathway
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
positive regulation of epithelial cell proliferation
positive regulation of interleukin-1 beta secretion
regulation of inflammatory response
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of phagocytosis
defense response to Gram-positive bacterium
positive regulation of B cell activation
positive regulation of NF-kappaB transcription factor activity
protein oligomerization
positive regulation of oxidoreductase activity
positive regulation of nitric-oxide synthase biosynthetic process
positive regulation of prostaglandin-endoperoxide synthase activity
positive regulation of ERK1 and ERK2 cascade
nucleotide-binding oligomerization domain containing 2 signaling pathway
cellular response to peptidoglycan
cellular response to muramyl dipeptide
macrophage inflammatory protein-1 alpha production
regulation of neutrophil chemotaxis
positive regulation of cytokine production involved in inflammatory response
negative regulation of macrophage apoptotic process
positive regulation of prostaglandin-E synthase activity

Function(s)

nucleotide binding
protein binding
ATP binding
endodeoxyribonuclease activity, producing 5'-phosphomonoesters
enzyme binding
protein kinase binding
muramyl dipeptide binding
peptidoglycan binding
CARD domain binding