155175

• Gene Symbol: Lrp6
• Gene Name: low density lipoprotein receptor-related protein 6
• Gene Aliases: C030016K15Rik, Cd, Gw, ska26, ska<m26Jus>, skax26
• Chromosome Location: Chr.6: 134446476 - 134566960 on Build GRCm38
• UniGene ID: Mm.321990
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Lrp6
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_008514.4	NP_032540.2	2	648
GenBank mRNA	AF074265.1	-	2	517
	AK021086.1	-	1	46
	BC060704.1	-	2	648	6409058

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001107892, XM_006237519.

Panther Classification:

Molecular Function -

apolipoprotein

Gene Ontology Categories:

Process(es)

gastrulation with mouth forming second
somitogenesis
neural tube closure
negative regulation of protein phosphorylation
heart looping
morphogenesis of an epithelium
positive regulation of mesenchymal cell proliferation
pericardium morphogenesis
axis elongation
regulation of transcription, DNA-templated
negative regulation of protein kinase activity
endocytosis
receptor-mediated endocytosis
positive regulation of cytosolic calcium ion concentration
chemical synaptic transmission
multicellular organism development
embryonic pattern specification
dorsal/ventral axis specification
anterior/posterior pattern specification
neural crest formation
neural crest cell differentiation
Wnt signaling pathway
single organismal cell-cell adhesion
cerebellum morphogenesis
thalamus development
cerebral cortex cell migration
forebrain radial glial cell differentiation
forebrain generation of neurons
Wnt signaling pathway involved in forebrain neuroblast division
neural tube development
formation of radial glial scaffolds
cerebral cortex development
negative regulation of Wnt signaling pathway
embryonic limb morphogenesis
forebrain development
midbrain development
midbrain-hindbrain boundary development
negative regulation of smooth muscle cell apoptotic process
limb morphogenesis
embryonic forelimb morphogenesis
embryonic hindlimb morphogenesis
external genitalia morphogenesis
post-anal tail morphogenesis
cell migration involved in gastrulation
regulation of cell proliferation
odontogenesis of dentin-containing tooth
embryonic digit morphogenesis
positive regulation of apoptotic process
Wnt signaling pathway involved in dorsal/ventral axis specification
negative regulation of fat cell differentiation
positive regulation of ossification
positive regulation of bone resorption
positive regulation of cell cycle
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
bone remodeling
embryonic camera-type eye morphogenesis
generation of neurons
skeletal system morphogenesis
negative regulation of epithelial cell proliferation
positive regulation of sequence-specific DNA binding transcription factor activity
response to folic acid
palate development
convergent extension
retina morphogenesis in camera-type eye
embryonic retina morphogenesis in camera-type eye
canonical Wnt signaling pathway
regulation of cell development
face morphogenesis
bone morphogenesis
branching involved in mammary gland duct morphogenesis
trachea cartilage morphogenesis
mammary placode formation
mammary gland duct morphogenesis
canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development
canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation
cellular response to cholesterol
dopaminergic neuron differentiation
negative regulation of protein serine/threonine kinase activity
primitive streak formation
receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport
Wnt signaling pathway involved in somitogenesis
axis elongation involved in somitogenesis
positive regulation of canonical Wnt signaling pathway
toxin transport
negative regulation of non-canonical Wnt signaling pathway
positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification
negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis
negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis
negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis
negative regulation of planar cell polarity pathway involved in pericardium morphogenesis
negative regulation of planar cell polarity pathway involved in neural tube closure

Function(s)

low-density lipoprotein receptor activity
receptor binding
frizzled binding
protein binding
Wnt-protein binding
kinase inhibitor activity
toxin transporter activity
apolipoprotein binding
identical protein binding
protein homodimerization activity
Wnt-activated receptor activity
coreceptor activity involved in Wnt signaling pathway