155242

• Gene Symbol: Smad7
• Gene Name: SMAD family member 7
• Gene Aliases: Madh7
• Chromosome Location: Chr.18: 75367365 - 75395935 on Build GRCm38
• UniGene ID: Mm.34407
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Smad7
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001042660.1	NP_001036125.1	4	2499
GenBank mRNA	AB221688.1	-	4	908
	AF015260.1	-	4	908
	AJ000550.1	-	4	2344
	AJ000551.1	-	4	905
	BC137638.1	-	4	981	8860657

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_001190821, NM_005904, NM_001190822, NM_001190823, BC074819, and others.
This siRNA also targets the following transcripts in Rat: NM_030858, XM_006254959, AF159626, AF042499.

Panther Classification:

Molecular Function -

DNA-binding transcription factor, gene-specific transcriptional regulator

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
transforming growth factor beta receptor signaling pathway
negative regulation of peptidyl-threonine phosphorylation
negative regulation of transcription by competitive promoter binding
regulation of transforming growth factor beta receptor signaling pathway
positive regulation of cell-cell adhesion
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of BMP signaling pathway
negative regulation of protein ubiquitination
positive regulation of protein ubiquitination
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of activin receptor signaling pathway
negative regulation of peptidyl-serine phosphorylation
adherens junction assembly
cellular protein complex localization
intracellular signal transduction
negative regulation of sequence-specific DNA binding transcription factor activity
artery morphogenesis
protein stabilization
negative regulation of ubiquitin-protein transferase activity
ventricular cardiac muscle tissue morphogenesis
regulation of cardiac muscle contraction
regulation of ventricular cardiac muscle cell membrane depolarization
pathway-restricted SMAD protein phosphorylation
negative regulation of pathway-restricted SMAD protein phosphorylation
ventricular septum morphogenesis
cellular response to transforming growth factor beta stimulus

Function(s)

DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
collagen binding
beta-catenin binding
transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
ubiquitin protein ligase binding
type I transforming growth factor beta receptor binding
transcription regulatory region DNA binding
metal ion binding
activin binding
I-SMAD binding