155433

• Gene Symbol: Msh2
• Gene Name: mutS homolog 2 (E. coli)
• Gene Aliases: AI788990
• Chromosome Location: Chr.17: 87672557 - 87723713 on Build GRCm38
• UniGene ID: Mm.4619
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Msh2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_008628.2	NP_032654.1	16	3024
GenBank mRNA	AK157842.1	-	16	3037
	AK166179.1	-	16	3014
	BC047117.1	-	16	3032	4951173
	BC050897.1	-	16	3007	6401835
	U21011.1	-	16	3044
	X81143.1	-	16	3024

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_031058, BC161846, X93591.

Panther Classification:

Molecular Function -

DNA metabolism protein

Gene Ontology Categories:

Process(es)

meiotic mismatch repair
in utero embryonic development
somatic recombination of immunoglobulin genes involved in immune response
oxidative phosphorylation
DNA repair
mismatch repair
postreplication repair
double-strand break repair
meiotic gene conversion
cellular response to DNA damage stimulus
cell cycle
cell cycle arrest
reciprocal meiotic recombination
germ cell development
determination of adult lifespan
male gonad development
intrinsic apoptotic signaling pathway in response to DNA damage
response to X-ray
response to UV-B
somatic hypermutation of immunoglobulin genes
somatic recombination of immunoglobulin gene segments
B cell mediated immunity
B cell differentiation
intra-S DNA damage checkpoint
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
negative regulation of neuron apoptotic process
maintenance of DNA repeat elements
negative regulation of reciprocal meiotic recombination
isotype switching
negative regulation of DNA recombination
positive regulation of helicase activity

Function(s)

nucleotide binding
magnesium ion binding
four-way junction DNA binding
Y-form DNA binding
heteroduplex DNA loop binding
double-strand/single-strand DNA junction binding
DNA binding
damaged DNA binding
double-stranded DNA binding
single-stranded DNA binding
ATP binding
protein C-terminus binding
DNA-dependent ATPase activity
ATPase activity
centromeric DNA binding
enzyme binding
protein kinase binding
mismatched DNA binding
guanine/thymine mispair binding
single base insertion or deletion binding
dinucleotide insertion or deletion binding
single guanine insertion binding
single thymine insertion binding
dinucleotide repeat insertion binding
oxidized purine DNA binding
MutLalpha complex binding
protein homodimerization activity
ADP binding