156077

• Gene Symbol: Lck
• Gene Name: lymphocyte protein tyrosine kinase
• Gene Aliases: Hck-3, Lsk, Lskt, p56<lck>, p56Lck
• Chromosome Location: Chr.4: 129548344 - 129573641 on Build GRCm38
• UniGene ID: Mm.293753
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Lck
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001162432.1	NP_001155904.1	12	1329
	NM_001162433.1	NP_001155905.1	12	1371
	NM_010693.3	NP_034823.1	11	1426
GenBank mRNA	AK088001.1	-	11	1427
	AK166263.1	-	6	816
	BC011474.1	-	12	1336	4191610
	CX217876.1	-	4	585
	M12056.1	-	11	1402
	X03533.1	-	11	1432

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001100709, XM_006238932, XM_006238933, XM_008764140, BC160881, and others.

Gene Ontology Categories:

Process(es)

protein phosphorylation
activation of cysteine-type endopeptidase activity involved in apoptotic process
cell surface receptor signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
response to mechanical stimulus
response to metal ion
positive regulation of gene expression
phosphorylation
dephosphorylation
peptidyl-tyrosine phosphorylation
T cell differentiation
peptidyl-tyrosine autophosphorylation
regulation of cell proliferation
response to drug
positive regulation of tyrosine phosphorylation of Stat5 protein
response to hydrogen peroxide
regulation of apoptotic process
innate immune response
positive regulation of gamma-delta T cell differentiation
protein autophosphorylation
B cell receptor signaling pathway
regulation of T cell receptor signaling pathway
positive regulation of T cell activation
release of sequestered calcium ion into cytosol
positive regulation of uterine smooth muscle contraction
cellular response to peptide hormone stimulus
positive regulation of intrinsic apoptotic signaling pathway

Function(s)

nucleotide binding
glycoprotein binding
antigen binding
protein kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
protein serine/threonine phosphatase activity
receptor binding
protein binding
ATP binding
protein C-terminus binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein kinase binding
protein phosphatase binding
protein complex binding
SH2 domain binding
CD4 receptor binding
CD8 receptor binding
identical protein binding
phosphatidylinositol 3-kinase binding
ATPase binding