157134

• Gene Symbol: Mef2c
• Gene Name: myocyte enhancer factor 2C
• Gene Aliases: 5430401D19Rik, 9930028G15Rik, AV011172, Mef2
• Chromosome Location: Chr.13: 83504034 - 83667079 on Build GRCm38
• UniGene ID: Mm.24001
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Mef2c
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001170537.1	NP_001164008.1	11	2382
	NM_025282.3	NP_079558.1	11	2280
GenBank mRNA	AK009139.1	-	11	2122
	AK077603.1	-	10	2083
	AK132573.1	-	11	2210
	BC026841.1	-	11	2041	4481227
	BC037731.1	-	11	2128	4500786
	BC057650.1	-	11	2117	4500786

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_002397, NM_001193347, NM_001193350, NM_001193348, NM_001193349, and others.
This siRNA also targets the following transcripts in Rat: XM_008760642, XM_006231736, XM_006231738, XM_006231731, XM_006231739, and others.

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
MAPK cascade
blood vessel development
osteoblast differentiation
neuron migration
B cell homeostasis
heart looping
endochondral ossification
blood vessel remodeling
chondrocyte differentiation
germinal center formation
regulation of germinal center formation
response to ischemia
primary heart field specification
secondary heart field specification
outflow tract morphogenesis
sinoatrial valve morphogenesis
cardiac ventricle formation
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
apoptotic process
humoral immune response
multicellular organism development
nervous system development
heart development
skeletal muscle tissue development
muscle cell fate determination
learning or memory
positive regulation of cardiac muscle hypertrophy
positive regulation of gene expression
negative regulation of gene expression
positive regulation of alkaline phosphatase activity
neural crest cell differentiation
cardiac muscle hypertrophy in response to stress
cell differentiation
neuron differentiation
platelet formation
monocyte differentiation
negative regulation of ossification
melanocyte differentiation
positive regulation of bone mineralization
positive regulation of B cell proliferation
cellular response to drug
skeletal muscle cell differentiation
cellular response to trichostatin A
B cell proliferation
positive regulation of MAP kinase activity
regulation of neuron apoptotic process
negative regulation of neuron apoptotic process
cell fate commitment
regulation of megakaryocyte differentiation
positive regulation of myoblast differentiation
positive regulation of neuron differentiation
positive regulation of osteoblast differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of neurotransmitter secretion
regulation of synaptic plasticity
positive regulation of skeletal muscle tissue development
neuron development
cell morphogenesis involved in neuron differentiation
embryonic viscerocranium morphogenesis
embryonic skeletal system morphogenesis
negative regulation of epithelial cell proliferation
B cell receptor signaling pathway
smooth muscle cell differentiation
regulation of synapse assembly
regulation of synaptic transmission, glutamatergic
cardiac muscle cell differentiation
ventricular cardiac muscle cell differentiation
palate development
regulation of synaptic activity
positive regulation of cardiac muscle cell proliferation
excitatory postsynaptic potential
transdifferentiation
regulation of sarcomere organization
cartilage morphogenesis
regulation of dendritic spine development
renal tubule morphogenesis
cellular response to lipopolysaccharide
cellular response to calcium ion
cellular response to retinoic acid
cellular response to growth factor stimulus
cellular response to parathyroid hormone stimulus
cellular response to fluid shear stress
cellular response to transforming growth factor beta stimulus
positive regulation of cell proliferation in bone marrow
glomerulus morphogenesis
nephron tubule epithelial cell differentiation
positive regulation of protein homodimerization activity
positive regulation of macrophage apoptotic process
regulation of N-methyl-D-aspartate selective glutamate receptor activity
regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
positive regulation of cardiac muscle cell differentiation
positive regulation of behavioral fear response
epithelial cell proliferation involved in renal tubule morphogenesis
positive regulation of skeletal muscle cell differentiation

Function(s)

RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter sequence-specific
core promoter proximal region sequence-specific DNA binding
core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
DNA binding
AT DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
activating transcription factor binding
miRNA binding
histone deacetylase binding
sequence-specific DNA binding
transcription regulatory region DNA binding
protein heterodimerization activity
protein dimerization activity
HMG box domain binding