158033

• Gene Symbol: Hes1
• Gene Name: hairy and enhancer of split 1 (Drosophila)
• Gene Aliases: Hry, bHLHb39
• Chromosome Location: Chr.16: 30065357 - 30067796 on Build GRCm38
• UniGene ID: Mm.390859
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Hes1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_008235.2	NP_032261.1	4	1244
GenBank mRNA	AK132536.1	-	4	1256
	AK133538.1	-	4	1260
	BC018375.1	-	4	1244	4505427
	BC051428.1	-	4	1245	6478994

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_005524, AK000415, BC039152, AF264785.
This siRNA also targets the following transcripts in Rat: NM_024360, D13417, BC061730.

Panther Classification:

Molecular Function -

basic helix-loop-helix transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
liver development
embryonic heart tube morphogenesis
outflow tract morphogenesis
regulation of secondary heart field cardioblast proliferation
ventricular septum development
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
protein complex assembly
cell adhesion
Notch signaling pathway
smoothened signaling pathway
STAT protein import into nucleus
pattern specification process
positive regulation of cell proliferation
positive regulation of gene expression
negative regulation of gene expression
negative regulation of neuron projection development
cell migration
telencephalon development
midbrain-hindbrain boundary morphogenesis
oculomotor nerve development
trochlear nerve development
hindbrain morphogenesis
forebrain radial glial cell differentiation
neural tube development
pituitary gland development
adenohypophysis development
lung development
positive regulation of BMP signaling pathway
midbrain development
pancreas development
somatic stem cell population maintenance
hair cell differentiation
aorta morphogenesis
ascending aorta morphogenesis
positive regulation of T cell proliferation
auditory receptor cell differentiation
positive regulation of tyrosine phosphorylation of Stat3 protein
auditory receptor cell fate determination
positive regulation of DNA binding
regulation of protein heterodimerization activity
cell fate commitment
negative regulation of cell differentiation
regulation of fat cell differentiation
negative regulation of auditory receptor cell differentiation
negative regulation of neuron differentiation
positive regulation of glial cell differentiation
positive regulation of Notch signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of mitotic cell cycle, embryonic
lateral inhibition
positive regulation of JAK-STAT cascade
cell maturation
regulation of timing of cell differentiation
thymus development
cell morphogenesis involved in neuron differentiation
positive regulation of astrocyte differentiation
negative regulation of oligodendrocyte differentiation
artery morphogenesis
regulation of neurogenesis
negative regulation of neurogenesis
regulation of timing of neuron differentiation
negative regulation of glial cell proliferation
ventricular septum morphogenesis
labyrinthine layer blood vessel development
common bile duct development
negative regulation of stomach neuroendocrine cell differentiation
cardiac neural crest cell development involved in outflow tract morphogenesis
pharyngeal arch artery morphogenesis
cochlea development
negative regulation of calcium ion import
vascular smooth muscle cell development
neuronal stem cell population maintenance
negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
positive regulation of protein targeting to mitochondrion
cellular response to nerve growth factor stimulus
negative regulation of pancreatic A cell differentiation
negative regulation of stem cell differentiation
negative regulation of pro-B cell differentiation
negative regulation of forebrain neuron differentiation
negative regulation of inner ear receptor cell differentiation

Function(s)

RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
JUN kinase binding
protein complex binding
protein homodimerization activity
histone deacetylase binding
sequence-specific DNA binding
protein dimerization activity
chaperone binding
E-box binding
N-box binding