158741

• Gene Symbol: Gclc
• Gene Name: glutamate-cysteine ligase, catalytic subunit
• Gene Aliases: D9Wsu168e, GLCL-H, Ggcs-hs, Glclc
• Chromosome Location: Chr.9: 77754516 - 77794489 on Build GRCm38
• UniGene ID: Mm.89888
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Gclc
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_010295.2	NP_034425.1	15	1963
GenBank mRNA	AK144339.1	-	15	1964
	AK160876.1	-	15	1723
	AK169676.1	-	15	1936
	BC019374.1	-	15	1720	4195425
	U85414.1	-	15	1688
	U85498.1	-	15	1688

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_001498, NM_001197115, AB262176, BC047788, BC039894, and others.
This siRNA also targets the following transcripts in Rat: NM_012815, BC081702, J05181.

Panther Classification:

Molecular Function -

ligase

Gene Ontology Categories:

Process(es)

cysteine metabolic process
glutamate metabolic process
glutathione metabolic process
glutathione biosynthetic process
response to oxidative stress
apoptotic mitochondrial changes
response to heat
response to xenobiotic stimulus
response to hormone
L-ascorbic acid metabolic process
negative regulation of protein ubiquitination
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
cell redox homeostasis
negative regulation of transcription, DNA-templated
response to arsenic-containing substance
regulation of blood vessel size
response to nitrosative stress
regulation of mitochondrial depolarization
negative regulation of extrinsic apoptotic signaling pathway

Function(s)

nucleotide binding
magnesium ion binding
glutamate-cysteine ligase activity
ATP binding
glutamate binding
ligase activity
ADP binding
protein heterodimerization activity
coenzyme binding