160890

• Gene Symbol: Brca1
• Gene Name: breast cancer 1
• Gene Aliases: -
• Chromosome Location: Chr.11: 101488754 - 101551956 on Build GRCm38
• UniGene ID: Mm.244975
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Brca1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_009764.3	NP_033894.3	23	5711
GenBank mRNA	BC068303.1	-	23	5544	30431022
	U31625.1	-	23	5568
	U36475.1	-	22	5531

More Information

Panther Classification:

Molecular Function -

ubiquitin-protein ligase, protein modifying enzyme

Gene Ontology Categories:

Process(es)

double-strand break repair via homologous recombination
DNA replication
DNA repair
postreplication repair
double-strand break repair
DNA recombination
regulation of gene expression by genetic imprinting
lipid metabolic process
fatty acid metabolic process
fatty acid biosynthetic process
cellular response to DNA damage stimulus
cell cycle
chromosome segregation
centrosome cycle
intrinsic apoptotic signaling pathway in response to DNA damage
dosage compensation by inactivation of X chromosome
response to ionizing radiation
positive regulation of vascular endothelial growth factor production
positive regulation of gene expression
protein ubiquitination
chromosome breakage
positive regulation of protein ubiquitination
G2 DNA damage checkpoint
positive regulation of histone acetylation
negative regulation of histone acetylation
regulation of cell proliferation
chordate embryonic development
response to estrogen
regulation of DNA methylation
negative regulation of fatty acid biosynthetic process
positive regulation of DNA repair
positive regulation of angiogenesis
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
centrosome duplication
positive regulation of histone H3-K4 methylation
negative regulation of histone H3-K4 methylation
negative regulation of histone H3-K9 methylation
positive regulation of histone H3-K9 methylation
protein autoubiquitination
positive regulation of histone H4-K20 methylation
positive regulation of cell cycle arrest
cellular response to tumor necrosis factor
cellular response to indole-3-methanol
protein K6-linked ubiquitination
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of reactive oxygen species metabolic process
positive regulation of histone H3-K9 acetylation
positive regulation of histone H4-K16 acetylation

Function(s)

DNA binding
damaged DNA binding
RNA binding
ubiquitin-protein transferase activity
zinc ion binding
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ligase activity
ribosomal S6-glutamic acid ligase activity
enzyme binding
ubiquitin protein ligase binding
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
transcription regulatory region DNA binding
metal ion binding
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity