161008

• Gene Symbol: Casp8
• Gene Name: caspase 8
• Gene Aliases: CASP-8, FLICE, MACH, Mch5
• Chromosome Location: Chr.1: 58795229 - 58847503 on Build GRCm38
• UniGene ID: Mm.336851
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Casp8
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001080126.1	NP_001073595.1	9	1912
	NM_001277926.1	NP_001264855.1	10	2028
	NM_009812.2	NP_033942.1	9	2085
GenBank mRNA	AF067834.1	-	9	1965
	AK146758.1	-	9	2085
	AK168812.1	-	9	2085

More Information

Panther Classification:

Molecular Function -

protease

Gene Ontology Categories:

Process(es)

angiogenesis
neural tube formation
proteolysis
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
heart development
extrinsic apoptotic signaling pathway via death domain receptors
macrophage differentiation
response to tumor necrosis factor
TRAIL-activated apoptotic signaling pathway
regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
response to ethanol
positive regulation of macrophage differentiation
positive regulation of proteolysis
cardiac muscle tissue development
protein heterooligomerization
proteolysis involved in cellular protein catabolic process
negative regulation of necroptotic process
regulation of thymocyte apoptotic process
apoptotic signaling pathway
extrinsic apoptotic signaling pathway
execution phase of apoptosis
activation of cysteine-type endopeptidase activity
hepatocyte apoptotic process
regulation of apoptotic signaling pathway
positive regulation of extrinsic apoptotic signaling pathway

Function(s)

endopeptidase activity
cysteine-type endopeptidase activity
death receptor binding
tumor necrosis factor receptor binding
protein binding
peptidase activity
cysteine-type peptidase activity
hydrolase activity
ubiquitin protein ligase binding
protein complex binding
death effector domain binding
protein heterodimerization activity
scaffold protein binding
cysteine-type endopeptidase activity involved in apoptotic process
cysteine-type endopeptidase activity involved in apoptotic signaling pathway