16131

• Gene Symbol: HSPA5
• Gene Name: heat shock protein family A (Hsp70) member 5
• Gene Aliases: BIP, GRP78, HEL-S-89n, MIF2
• Chromosome Location: Chr.9: 125234848 - 125241387 on Build GRCh38
• UniGene ID: Hs.743241
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: HSPA5
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_005347.4	NP_005338.1	2, 3	623
GenBank mRNA	AF188611.1	-	2, 3	308
	AF216292.1	-	2, 3	362
	AJ271729.1	-	2, 3	375
	AK293604.1	-	2, 3	579
	BC020235.1	-	2, 3	566	5020098
	EU794617.1	-	2, 3	375
	X87949.1	-	2, 3	584

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_013083, M14050, BC062017, CB578015.
This siRNA also targets the following transcripts in Mouse: NM_022310, NM_001163434, AK004578, AK195133, AK146647, and others.

Gene Ontology Categories:

Process(es)

ER overload response
activation of signaling protein activity involved in unfolded protein response
cerebellum structural organization
cerebellar Purkinje cell layer development
substantia nigra development
positive regulation of cell migration
ER-associated ubiquitin-dependent protein catabolic process
negative regulation of transforming growth factor beta receptor signaling pathway
endoplasmic reticulum unfolded protein response
positive regulation of protein ubiquitination
protein folding in endoplasmic reticulum
maintenance of protein localization in endoplasmic reticulum
IRE1-mediated unfolded protein response
PERK-mediated unfolded protein response
ATF6-mediated unfolded protein response
cellular response to glucose starvation
negative regulation of apoptotic process
regulation of protein folding in endoplasmic reticulum
cellular response to antibiotic
cellular response to manganese ion
cellular response to interleukin-4
negative regulation of protein homodimerization activity
cell-cell adhesion
toxin transport
regulation of ATF6-mediated unfolded protein response
regulation of IRE1-mediated unfolded protein response
regulation of PERK-mediated unfolded protein response
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

Function(s)

glycoprotein binding
calcium ion binding
protein binding
ATP binding
ATPase activity
enzyme binding
protein domain specific binding
ubiquitin protein ligase binding
ribosome binding
unfolded protein binding
chaperone binding
misfolded protein binding
cadherin binding involved in cell-cell adhesion