16489

• Gene Symbol: HES1
• Gene Name: hes family bHLH transcription factor 1
• Gene Aliases: HES-1, HHL, HRY, bHLHb39
• Chromosome Location: Chr.3: 194136142 - 194138612 on Build GRCh38
• UniGene ID: Hs.250666
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: HES1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_005524.3	NP_005515.1	4	1182
GenBank mRNA	AF264785.1	-	4	943
	AK000415.1	-	4	1179
	BC039152.1	-	4	1130	4749611

More Information

Panther Classification:

Molecular Function -

basic helix-loop-helix transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
liver development
embryonic heart tube morphogenesis
outflow tract morphogenesis
regulation of secondary heart field cardioblast proliferation
ventricular septum development
transcription, DNA-templated
protein complex assembly
cell adhesion
Notch signaling pathway
smoothened signaling pathway
STAT protein import into nucleus
nervous system development
positive regulation of cell proliferation
cell migration
telencephalon development
midbrain-hindbrain boundary morphogenesis
oculomotor nerve development
trochlear nerve development
hindbrain morphogenesis
forebrain radial glial cell differentiation
adenohypophysis development
lung development
positive regulation of BMP signaling pathway
midbrain development
pancreas development
somatic stem cell population maintenance
ascending aorta morphogenesis
positive regulation of T cell proliferation
positive regulation of tyrosine phosphorylation of Stat3 protein
auditory receptor cell fate determination
positive regulation of DNA binding
regulation of fat cell differentiation
negative regulation of auditory receptor cell differentiation
positive regulation of Notch signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of mitotic cell cycle, embryonic
lateral inhibition
positive regulation of JAK-STAT cascade
cell maturation
thymus development
cell morphogenesis involved in neuron differentiation
positive regulation of astrocyte differentiation
negative regulation of oligodendrocyte differentiation
artery morphogenesis
regulation of epithelial cell proliferation
inner ear receptor stereocilium organization
regulation of timing of neuron differentiation
negative regulation of glial cell proliferation
ventricular septum morphogenesis
ureteric bud morphogenesis
labyrinthine layer blood vessel development
common bile duct development
negative regulation of stomach neuroendocrine cell differentiation
cardiac neural crest cell development involved in outflow tract morphogenesis
pharyngeal arch artery morphogenesis
glomerulus vasculature development
comma-shaped body morphogenesis
S-shaped body morphogenesis
renal interstitial fibroblast development
metanephric nephron tubule morphogenesis
cochlea development
establishment of epithelial cell polarity
vascular smooth muscle cell development
neuronal stem cell population maintenance
positive regulation of protein targeting to mitochondrion
negative regulation of pancreatic A cell differentiation
negative regulation of stem cell differentiation
negative regulation of pro-B cell differentiation
negative regulation of forebrain neuron differentiation

Function(s)

transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
protein homodimerization activity
histone deacetylase binding
sequence-specific DNA binding
chaperone binding
N-box binding