17156

• Gene Symbol: HDAC6
• Gene Name: histone deacetylase 6
• Gene Aliases: CPBHM, HD6, JM21, PPP1R90
• Chromosome Location: Chr.X: 48801377 - 48824982 on Build GRCh38
• UniGene ID: Hs.6764
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: HDAC6
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001321225.1	NP_001308154.1	4	311
	NM_001321226.1	NP_001308155.1	3	721
	NM_001321227.1	NP_001308156.1	3	442
	NM_001321228.1	NP_001308157.1	3	405
	NM_001321229.1	NP_001308158.1	3	259
	NM_001321230.1	NP_001308159.1	3	442
	NM_001321231.1	NP_001308160.1	3	721
	NM_006044.3	NP_006035.2	3	312
	NR_135591.1		2	185
	NR_135592.1		2	319
	NR_135593.1		2	319
	XM_017029187.1	XP_016884676.1	3	234
GenBank mRNA	AB020708.1	-	3	227
	AF132609.1	-	2	155
	AJ011972.1	-	3	248
	AK024083.1	-	3	254
	AK095124.1	-	3	265
	AK295884.1	-	2	172
	AK302926.1	-	3	250
	AL137696.1	-	3	276
	BC005872.1	-	3	681
	BC011498.1	-	3	268
	BC013737.1	-	2	137	2984860
	BC069243.1	-	3	254	6584427
	BT006649.1	-	2	155
	DA191923.1	-	2	128
	DC402494.1	-	4	311

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: XM_006256756, XM_228753, XM_003752010, XM_006256759, XM_006256755, and others.
This siRNA also targets the following transcripts in Mouse: NM_010413, NM_001130416, AK155546, AK148092, AK148144, and others.

Panther Classification:

Molecular Function -

chromatin/chromatin-binding, or -regulatory protein, histone modifying enzyme

Gene Ontology Categories:

Process(es)

protein polyubiquitination
transcription, DNA-templated
protein deacetylation
misfolded or incompletely synthesized protein catabolic process
intracellular protein transport
organelle organization
negative regulation of microtubule depolymerization
response to toxic substance
positive regulation of signal transduction
response to organic substance
regulation of receptor activity
regulation of autophagy
positive regulation of epithelial cell migration
negative regulation of hydrogen peroxide metabolic process
positive regulation of receptor biosynthetic process
macroautophagy
histone deacetylation
regulation of protein stability
lysosome localization
peptidyl-lysine deacetylation
cellular response to topologically incorrect protein
regulation of gene expression, epigenetic
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
protein complex disassembly
negative regulation of protein complex disassembly
regulation of fat cell differentiation
negative regulation of proteolysis
negative regulation of transcription, DNA-templated
negative regulation of oxidoreductase activity
mitochondrion localization
response to misfolded protein
regulation of microtubule-based movement
regulation of androgen receptor signaling pathway
regulation of establishment of protein localization
cellular response to hydrogen peroxide
aggresome assembly
polyubiquitinated misfolded protein transport
Hsp90 deacetylation
response to growth factor
histone H3 deacetylation
cellular response to misfolded protein
positive regulation of chaperone-mediated protein complex assembly
tubulin deacetylation
mitophagy in response to mitochondrial depolarization
positive regulation of hydrogen peroxide-mediated programmed cell death
regulation of mitophagy

Function(s)

core promoter binding
actin binding
histone deacetylase activity
protein binding
beta-catenin binding
microtubule binding
zinc ion binding
enzyme binding
polyubiquitin binding
ubiquitin protein ligase binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
histone deacetylase binding
tubulin deacetylase activity
alpha-tubulin binding
tau protein binding
beta-tubulin binding
misfolded protein binding
Hsp90 protein binding
dynein complex binding