17205

• Gene Symbol: MTHFD1
• Gene Name: methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
• Gene Aliases: MTHFC, MTHFD
• Chromosome Location: Chr.14: 64388041 - 64460007 on Build GRCh38
• UniGene ID: Hs.652308
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: MTHFD1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_005956.3	NP_005947.3	3, 4	569
GenBank mRNA	AK302747.1	-	3, 4	579
	AK312361.1	-	3, 4	274
	BC009806.2	-	3, 4	235	3508998
	BC050420.1	-	3, 4	260	5788176
	BQ959308.1	-	3, 4	381
	J04031.1	-	3, 4	235

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: XM_008762232.
This siRNA also targets the following transcripts in Mouse: NM_138745, AK133848, AK042019, AK042958, AK088700, and others.

Gene Ontology Categories:

Process(es)

histidine biosynthetic process
neutrophil homeostasis
neural tube closure
purine nucleotide biosynthetic process
methionine metabolic process
one-carbon metabolic process
heart development
serine family amino acid metabolic process
serine family amino acid biosynthetic process
methionine biosynthetic process
10-formyltetrahydrofolate biosynthetic process
transsulfuration
tetrahydrofolate interconversion
folic acid metabolic process
embryonic neurocranium morphogenesis
embryonic viscerocranium morphogenesis
oxidation-reduction process
somite development

Function(s)

formate-tetrahydrofolate ligase activity
methenyltetrahydrofolate cyclohydrolase activity
methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity
methylenetetrahydrofolate dehydrogenase (NAD+) activity
methylenetetrahydrofolate dehydrogenase (NADP+) activity
protein binding
ATP binding