172242

• Gene Symbol: Egln1
• Gene Name: egl-9 family hypoxia-inducible factor 1
• Gene Aliases: AI503754, C1orf12, HIF-PH2, HPH-2, Hif-p4h-2, ORF13, Phd2, SM-20
• Chromosome Location: Chr.8: 124908586 - 124949319 on Build GRCm38
• UniGene ID: Mm.140619
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Egln1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_053207.2	NP_444437.2	3, 4	1287
GenBank mRNA	AF453878.1	-	3, 4	476
	AJ310546.1	-	3, 4	990
	BC006903.1	-	3, 4	287	3600175

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_022051, DQ975380, AL833885, AF229245, AJ310543, and others.

Gene Ontology Categories:

Process(es)

response to hypoxia
peptidyl-proline hydroxylation to 4-hydroxy-L-proline
negative regulation of cAMP catabolic process
oxygen homeostasis
negative regulation of sequence-specific DNA binding transcription factor activity
regulation of angiogenesis
negative regulation of cyclic-nucleotide phosphodiesterase activity
cardiac muscle tissue morphogenesis
oxidation-reduction process
heart trabecula formation
ventricular septum morphogenesis
labyrinthine layer development
response to nitric oxide

Function(s)

iron ion binding
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
enzyme binding
L-ascorbic acid binding
peptidyl-proline dioxygenase activity
peptidyl-proline 4-dioxygenase activity
metal ion binding
dioxygenase activity