17471

• Gene Symbol: PRMT5
• Gene Name: protein arginine methyltransferase 5
• Gene Aliases: HRMT1L5, IBP72, JBP1, SKB1, SKB1Hs
• Chromosome Location: Chr.14: 22920511 - 22929585 on Build GRCh38
• UniGene ID: Hs.367854
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: PRMT5
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001039619.2	NP_001034708.1	2	485
	NM_001282953.1	NP_001269882.1	2	485
	NM_001282955.1	NP_001269884.1	2	400
	NM_001282956.1	NP_001269885.1	2	485
	NM_006109.4	NP_006100.2	2	400
GenBank mRNA	AB451246.1	-	2	176
	AB451370.1	-	2	176
	AF015913.1	-	2	176
	AF167572.1	-	2	267
	AK075251.1	-	2	278
	AK301812.1	-	2	291
	AK302240.1	-	2	180
	AK315500.1	-	2	216
	AL833612.1	-	2	185
	BC025979.2	-	2	188	3833019
	CR456741.1	-	2	176

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001108867, CB814013.
This siRNA also targets the following transcripts in Mouse: NM_013768, AF167573, AK076346, AK084106, AK165165, and others.

Panther Classification:

Molecular Function -

protein modifying enzyme

Gene Ontology Categories:

Process(es)

spliceosomal snRNP assembly
DNA-templated transcription, termination
regulation of transcription, DNA-templated
regulation of mitotic nuclear division
cell proliferation
peptidyl-arginine methylation
peptidyl-arginine methylation, to symmetrical-dimethyl arginine
circadian regulation of gene expression
peptidyl-arginine N-methylation
endothelial cell activation
histone H4-R3 methylation
regulation of DNA methylation
negative regulation of cell differentiation
positive regulation of oligodendrocyte differentiation
regulation of ERK1 and ERK2 cascade
Golgi ribbon formation
liver regeneration
regulation of signal transduction by p53 class mediator
negative regulation of nucleic acid-templated transcription
positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway

Function(s)

core promoter sequence-specific DNA binding
transcription corepressor activity
protein binding
methyltransferase activity
methyl-CpG binding
histone-arginine N-methyltransferase activity
protein-arginine N-methyltransferase activity
protein complex binding
protein-arginine omega-N symmetric methyltransferase activity
ribonucleoprotein complex binding
histone methyltransferase activity (H4-R3 specific)
protein heterodimerization activity