176133

• Gene Symbol: Pcsk9
• Gene Name: proprotein convertase subtilisin/kexin type 9
• Gene Aliases: AI415265, AI747682, FH3, HCHOLA3, Narc1, PC9
• Chromosome Location: Chr.4: 106442334 - 106464325 on Build GRCm38
• UniGene ID: Mm.133268
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Pcsk9
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_153565.2	NP_705793.1	4	969
GenBank mRNA	AK043077.1	-	4	819
	AK149520.1	-	4	748
	AY273821.1	-	4	593
	BC038085.1	-	4	984	4502199

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_199253, AY847775, BC133063.

Panther Classification:

Molecular Function -

serine protease

Gene Ontology Categories:

Process(es)

negative regulation of receptor recycling
positive regulation of receptor internalization
proteolysis
lipid metabolic process
triglyceride metabolic process
phospholipid metabolic process
apoptotic process
lysosomal transport
steroid metabolic process
cholesterol metabolic process
cellular response to starvation
regulation of receptor activity
negative regulation of low-density lipoprotein particle clearance
protein processing
protein autoprocessing
neuron differentiation
low-density lipoprotein receptor particle metabolic process
low-density lipoprotein particle receptor catabolic process
regulation of low-density lipoprotein particle receptor catabolic process
positive regulation of low-density lipoprotein particle receptor catabolic process
cellular response to insulin stimulus
lipoprotein metabolic process
cholesterol homeostasis
regulation of neuron apoptotic process
positive regulation of neuron apoptotic process
negative regulation of receptor activity
negative regulation of sodium ion transmembrane transporter activity

Function(s)

serine-type endopeptidase activity
peptidase activity
serine-type peptidase activity
hydrolase activity
sodium channel inhibitor activity
low-density lipoprotein particle binding
receptor inhibitor activity
apolipoprotein binding
very-low-density lipoprotein particle binding
apolipoprotein receptor binding
protein self-association
poly(A) RNA binding
low-density lipoprotein particle receptor binding
very-low-density lipoprotein particle receptor binding