181637

• Gene Symbol: Park7
• Gene Name: Parkinson disease (autosomal recessive, early onset) 7
• Gene Aliases: DJ-1, Dj1
• Chromosome Location: Chr.4: 150897133 - 150914432 on Build GRCm38
• UniGene ID: Mm.277349
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Park7
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_020569.3	NP_065594.2	6	529
GenBank mRNA	AB015652.1	-	6	476
	AK146368.1	-	6	441
	AK153948.1	-	6	486
	BC002187.1	-	6	435	3487763
	GU361472.1	-	3	255

More Information

Gene Ontology Categories:

Process(es)

negative regulation of protein phosphorylation
synaptic transmission, dopaminergic
negative regulation of protein kinase activity
proteolysis
protein deglycosylation
autophagy
inflammatory response
response to oxidative stress
mitochondrion organization
single fertilization
cell proliferation
adult locomotory behavior
detoxification of copper ion
positive regulation of gene expression
negative regulation of gene expression
enzyme active site formation via L-cysteine sulfinic acid
methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione
lactate biosynthetic process
negative regulation of protein ubiquitination
negative regulation of protein binding
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of interleukin-8 production
positive regulation of peptidyl-serine phosphorylation
negative regulation of protein sumoylation
cellular response to oxidative stress
cellular response to reactive oxygen species
cellular response to glyoxal
negative regulation of protein catabolic process
response to hydrogen peroxide
hydrogen peroxide metabolic process
negative regulation of apoptotic process
regulation of neuron apoptotic process
negative regulation of neuron apoptotic process
positive regulation of transcription from RNA polymerase II promoter
glycolate biosynthetic process
negative regulation of protein export from nucleus
regulation of inflammatory response
detoxification of mercury ion
protein stabilization
positive regulation of sequence-specific DNA binding transcription factor activity
negative regulation of ubiquitin-protein transferase activity
dopamine uptake involved in synaptic transmission
regulation of mitochondrial membrane potential
membrane depolarization
oxidation-reduction process
membrane hyperpolarization
negative regulation of cell death
regulation of androgen receptor signaling pathway
cellular response to hydrogen peroxide
positive regulation of protein homodimerization activity
positive regulation of protein localization to nucleus
negative regulation of neuron death
positive regulation of superoxide dismutase activity
negative regulation of protein acetylation
positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of mitochondrial electron transport, NADH to ubiquinone
negative regulation of protein K48-linked deubiquitination
negative regulation of TRAIL-activated apoptotic signaling pathway
positive regulation of pyrroline-5-carboxylate reductase activity
positive regulation of tyrosine 3-monooxygenase activity
positive regulation of dopamine biosynthetic process
glyoxal catabolic process
positive regulation of L-dopa biosynthetic process
positive regulation of L-dopa decarboxylase activity
negative regulation of oxidative stress-induced cell death
negative regulation of oxidative stress-induced neuron death
negative regulation of hydrogen peroxide-induced cell death
negative regulation of hydrogen peroxide-induced neuron death
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
positive regulation of reactive oxygen species biosynthetic process
negative regulation of ubiquitin-specific protease activity
positive regulation of oxidative phosphorylation uncoupler activity
positive regulation of transcription regulatory region DNA binding
positive regulation of androgen receptor activity
negative regulation of extrinsic apoptotic signaling pathway
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Function(s)

transcription coactivator activity
RNA binding
mRNA binding
histone deacetylase activity
receptor binding
copper ion binding
protein binding
transcription factor binding
peptidase activity
protein-N-terminal asparagine amidohydrolase activity
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CoA hydrolase activity
superoxide dismutase copper chaperone activity
oxidoreductase activity, acting on peroxide as acceptor
hydrolase activity
iprodione amidohydrolase activity
(3,5-dichlorophenylurea)acetate amidohydrolase activity
glyoxalase III activity
enzyme binding
kinase binding
cytokine binding
4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity
didemethylisoproturon amidohydrolase activity
N-isopropylacetanilide amidohydrolase activity
N-cyclohexylformamide amidohydrolase activity
2-oxoglutaryl-CoA thioesterase activity
2,4,4-trimethyl-3-oxopentanoyl-CoA thioesterase activity
isonicotinic acid hydrazide hydrolase activity
cis-aconitamide amidase activity
gamma-N-formylaminovinylacetate hydrolase activity
3-isopropylbut-3-enoyl-CoA thioesterase activity
tyrosine 3-monooxygenase activator activity
L-dopa decarboxylase activator activity
identical protein binding
protein homodimerization activity
N2-acetyl-L-lysine deacetylase activity
O-succinylbenzoate synthase activity
indoleacetamide hydrolase activity
N-acetylcitrulline deacetylase activity
small protein activating enzyme binding
ubiquitin-like protein conjugating enzyme binding
glutaryl-CoA hydrolase activity
mercury ion binding
N-acetylgalactosamine-6-phosphate deacetylase activity
acyl-CoA hydrolase activity
androgen receptor binding
peroxiredoxin activity
diacetylchitobiose deacetylase activity
chitooligosaccharide deacetylase activity
repressing transcription factor binding
scaffold protein binding
cupric ion binding
cuprous ion binding
ubiquitin-specific protease binding
glyoxalase (glycolic acid-forming) activity