184423

• Gene Symbol: Park2
• Gene Name: Parkinson disease (autosomal recessive, juvenile) 2, parkin
• Gene Aliases: PRKN
• Chromosome Location: Chr.17: 10840384 - 12063370 on Build GRCm38
• UniGene ID: Mm.311110
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Park2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_016694.3	NP_057903.1	11	1370
GenBank mRNA	AB019558.1	-	11	1341
	AF250293.1	-	11	1370
	AK015990.1	-	2	354
	BC113204.1	-	11	1353	40047891
	FJ555554.1	-	9	1123
	FJ555555.1	-	6	781
	FJ555556.1	-	10	1103
	FJ555557.1	-	10	1228
	GU272056.1	-	5	644

More Information

Gene Ontology Categories:

Process(es)

protein polyubiquitination
mitophagy
negative regulation of protein phosphorylation
synaptic transmission, dopaminergic
startle response
transcription, DNA-templated
regulation of transcription, DNA-templated
protein monoubiquitination
autophagy
response to unfolded protein
learning
locomotory behavior
adult locomotory behavior
proteasomal protein catabolic process
regulation of autophagy
positive regulation of gene expression
negative regulation of gene expression
positive regulation of mitochondrial fusion
regulation of mitochondrion organization
protein ubiquitination
protein metabolic process
regulation of protein ubiquitination
negative regulation of actin filament bundle assembly
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of glucokinase activity
response to endoplasmic reticulum stress
synaptic transmission, glutamatergic
regulation of dopamine metabolic process
norepinephrine metabolic process
dopamine metabolic process
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of DNA binding
negative regulation of neuron apoptotic process
cellular protein catabolic process
negative regulation by host of viral genome replication
positive regulation of transcription from RNA polymerase II promoter
negative regulation of insulin secretion
regulation of neurotransmitter secretion
modulation of synaptic transmission
protein stabilization
positive regulation of neurotransmitter uptake
dopamine uptake involved in synaptic transmission
mitochondrion localization
protein autoubiquitination
regulation of mitochondrial membrane potential
negative regulation of cell death
protein K63-linked ubiquitination
protein localization to mitochondrion
aggresome assembly
protein K48-linked ubiquitination
protein K11-linked ubiquitination
protein K6-linked ubiquitination
negative regulation of release of cytochrome c from mitochondria
cellular response to toxic substance
mitophagy in response to mitochondrial depolarization
regulation of cellular response to oxidative stress
negative regulation of neuron death
positive regulation of proteasomal protein catabolic process
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of primary amine oxidase activity
positive regulation of protein linear polyubiquitination
negative regulation of oxidative stress-induced neuron death
regulation of protein targeting to mitochondrion
positive regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
positive regulation of dendrite extension
negative regulation of spontaneous neurotransmitter secretion
regulation of reactive oxygen species metabolic process
negative regulation of reactive oxygen species metabolic process

Function(s)

G-protein coupled receptor binding
actin binding
ubiquitin-protein transferase activity
protein binding
zinc ion binding
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
tubulin binding
ligase activity
ribosomal S6-glutamic acid ligase activity
enzyme binding
kinase binding
protein kinase binding
PDZ domain binding
Hsp70 protein binding
heat shock protein binding
ubiquitin conjugating enzyme binding
ubiquitin protein ligase binding
protein complex binding
identical protein binding
histone deacetylase binding
ubiquitin binding
phospholipase binding
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
metal ion binding
chaperone binding
ubiquitin protein ligase activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
cullin family protein binding
ubiquitin-specific protease binding
F-box domain binding