186779

• Gene Symbol: Tnfaip3
• Gene Name: tumor necrosis factor, alpha-induced protein 3
• Gene Aliases: A20, Tnfip3
• Chromosome Location: Chr.10: 19000910 - 19015410 on Build GRCm38
• UniGene ID: Mm.116683
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Tnfaip3
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001166402.1	NP_001159874.1	6	1193
	NM_009397.3	NP_033423.3	7	1278
GenBank mRNA	AK088297.1	-	7	1235
	AK151921.1	-	7	1239
	AK153238.1	-	7	1233
	AK171326.1	-	6	1192
	AK172529.1	-	6	1195
	BC050259.1	-	6	2375
	BC054806.1	-	7	1278	6838303
	BC060221.1	-	7	1278	6843338
	CT010397.1	-	6	1005
	U19463.1	-	6	1005

More Information

Panther Classification:

Molecular Function -

cysteine protease

Gene Ontology Categories:

Process(es)

B-1 B cell homeostasis
response to molecule of bacterial origin
marginal zone B cell differentiation
negative regulation of granuloma formation
regulation of germinal center formation
regulation of immunoglobulin production
negative regulation of chronic inflammatory response
proteolysis
apoptotic process
inflammatory response
metabolic process
response to wounding
negative regulation of autophagy
protein deubiquitination
negative regulation of protein ubiquitination
negative regulation of NF-kappaB transcription factor activity
response to muramyl dipeptide
negative regulation of interleukin-1 beta production
negative regulation of interleukin-2 production
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
negative regulation of heterotypic cell-cell adhesion
negative regulation of toll-like receptor 3 signaling pathway
negative regulation of toll-like receptor 5 signaling pathway
protein K11-linked deubiquitination
negative regulation of I-kappaB kinase/NF-kappaB signaling
regulation of innate immune response
positive regulation of protein catabolic process
negative regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of innate immune response
negative regulation of smooth muscle cell proliferation
negative regulation of inflammatory response
negative regulation of B cell activation
negative regulation of cell death
cellular response to hydrogen peroxide
negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
protein K63-linked deubiquitination
protein K48-linked ubiquitination
protein K48-linked deubiquitination
cellular response to lipopolysaccharide
tolerance induction to lipopolysaccharide
establishment of protein localization to vacuole
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of cellular protein catabolic process
positive regulation of hepatocyte proliferation
negative regulation of CD40 signaling pathway
negative regulation of endothelial cell apoptotic process

Function(s)

protease binding
DNA binding
catalytic activity
ubiquitin-protein transferase activity
thiol-dependent ubiquitin-specific protease activity
protein binding
peptidase activity
cysteine-type peptidase activity
zinc ion binding
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
hydrolase activity
ligase activity
ribosomal S6-glutamic acid ligase activity
kinase binding
ubiquitin binding
protein self-association
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
metal ion binding
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity