187367

• Gene Symbol: Tnfsf11
• Gene Name: tumor necrosis factor (ligand) superfamily, member 11
• Gene Aliases: Ly109l, ODF, OPG, OPGL, RANKL, Trance
• Chromosome Location: Chr.14: 78277446 - 78308043 on Build GRCm38
• UniGene ID: Mm.249221
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Tnfsf11
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_011613.3	NP_035743.2	5	764
GenBank mRNA	AB008426.1	-	5	610
	AB032771.1	-	6	523
	AB032772.1	-	5	413
	AB036798.1	-	5	610
	AF013170.1	-	5	751
	AF019048.1	-	5	746
	AF053713.1	-	5	779
	AK159997.1	-	5	765
	BC125603.1	-	5	667	40130118
	BC131970.1	-	5	667	40130247

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_057149, XM_008770928, AF187319.

Gene Ontology Categories:

Process(es)

ossification
osteoclast proliferation
monocyte chemotaxis
immune response
activation of JUN kinase activity
multicellular organism development
organ morphogenesis
cytokine-mediated signaling pathway
cell differentiation
osteoclast differentiation
tumor necrosis factor-mediated signaling pathway
mammary gland epithelial cell proliferation
positive regulation of homotypic cell-cell adhesion
paracrine signaling
positive regulation of phosphorylation
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAP kinase activity
bone resorption
regulation of osteoclast differentiation
positive regulation of osteoclast differentiation
positive regulation of bone resorption
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
lymph node development
positive regulation of T cell activation
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
protein homooligomerization
positive regulation of corticotropin-releasing hormone secretion
positive regulation of protein kinase B signaling
calcium ion homeostasis
mammary gland alveolus development
ERK1 and ERK2 cascade
positive regulation of fever generation by positive regulation of prostaglandin secretion
TNFSF11-mediated signaling pathway
positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling
positive regulation of intracellular signal transduction
positive regulation of osteoclast development

Function(s)

cytokine activity
tumor necrosis factor receptor binding
protein binding
tumor necrosis factor receptor superfamily binding