187389

• Gene Symbol: Top2a
• Gene Name: topoisomerase (DNA) II alpha
• Gene Aliases: Top-2
• Chromosome Location: Chr.11: 98992947 - 99024206 on Build GRCm38
• UniGene ID: Mm.4237
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Top2a
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_011623.2	NP_035753.2	8	1055
GenBank mRNA	BC008170.1	-	8	1043
	BC057873.1	-	8	1025
	D12513.1	-	8	981

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_022183, Z19552.

Panther Classification:

Molecular Function -

DNA metabolism protein

Gene Ontology Categories:

Process(es)

resolution of meiotic recombination intermediates
sister chromatid segregation
hematopoietic progenitor cell differentiation
DNA metabolic process
DNA topological change
DNA ligation
DNA unwinding involved in DNA replication
cellular response to DNA damage stimulus
chromosome segregation
chromosome condensation
apoptotic chromosome condensation
embryonic cleavage
regulation of circadian rhythm
positive regulation of apoptotic process
mitotic DNA integrity checkpoint
positive regulation of viral genome replication
positive regulation of single stranded viral RNA replication via double stranded DNA intermediate
positive regulation of transcription from RNA polymerase II promoter
rhythmic process

Function(s)

nucleotide binding
magnesium ion binding
DNA binding
chromatin binding
DNA topoisomerase activity
DNA topoisomerase type II (ATP-hydrolyzing) activity
protein kinase C binding
ATP binding
protein C-terminus binding
DNA-dependent ATPase activity
drug binding
DNA binding, bending
isomerase activity
enzyme binding
protein homodimerization activity
histone deacetylase binding
ubiquitin binding
sequence-specific DNA binding
structure-specific DNA binding
poly(A) RNA binding
metal ion binding
protein heterodimerization activity