187424

• Gene Symbol: Trp53
• Gene Name: transformation related protein 53
• Gene Aliases: Tp53, bbl, bfy, bhy, p44, p53
• Chromosome Location: Chr.11: 69580359 - 69591873 on Build GRCm38
• UniGene ID: Mm.222
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Trp53
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001127233.1	NP_001120705.1	10	1209
	NM_011640.3	NP_035770.2	10	1209
GenBank mRNA	AB017815.1	-	10	1153
	AB017816.1	-	10	1153
	AB020317.1	-	10	1153
	AB021961.1	-	10	1152
	AB221571.1	-	9	1052
	AF051368.1	-	10	1077
	AF151353.1	-	10	1174
	AF161020.1	-	9	1062
	AJ297973.1	-	8	978
	AK147815.1	-	10	1166
	AY044188.1	-	9	1052
	AY212017.1	-	10	1163
	BC005448.1	-	10	1180	3599812
	EU031806.1	-	10	1114
	KF766124.1	-	10	908
	M13872.1	-	10	1164
	M13873.1	-	10	1120
	M13874.1	-	10	1105
	X00741.1	-	10	1171
	X01237.1	-	10	1209

More Information

Panther Classification:

Molecular Function -

P53-like transcription factor

Gene Ontology Categories:

Process(es)

protein import into nucleus, translocation
negative regulation of transcription from RNA polymerase II promoter
DNA strand renaturation
in utero embryonic development
somitogenesis
release of cytochrome c from mitochondria
T cell proliferation involved in immune response
B cell lineage commitment
T cell lineage commitment
positive regulation of leukocyte migration
response to ischemia
nucleotide-excision repair
double-strand break repair
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
protein complex assembly
apoptotic process
cellular response to DNA damage stimulus
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
response to oxidative stress
ER overload response
cell cycle
cell cycle arrest
transforming growth factor beta receptor signaling pathway
multicellular organism development
gastrulation
negative regulation of neuroblast proliferation
central nervous system development
cell aging
protein localization
negative regulation of DNA replication
negative regulation of cell proliferation
determination of adult lifespan
rRNA transcription
response to UV
response to salt stress
embryo development ending in birth or egg hatching
response to X-ray
response to gamma radiation
positive regulation of cardiac muscle cell apoptotic process
programmed cell death
viral process
cerebellum development
negative regulation of cell growth
DNA damage response, signal transduction by p53 class mediator
negative regulation of transforming growth factor beta receptor signaling pathway
chromosome breakage
positive regulation of histone deacetylation
chromatin assembly
mitotic G1 DNA damage checkpoint
positive regulation of protein oligomerization
T cell differentiation in thymus
regulation of tissue remodeling
cellular protein localization
cellular response to UV
multicellular organism growth
positive regulation of mitochondrial membrane permeability
regulation of cell proliferation
cellular response to glucose starvation
response to drug
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
regulation of apoptotic process
positive regulation of apoptotic process
negative regulation of apoptotic process
entrainment of circadian clock by photoperiod
mitochondrial DNA repair
regulation of neuron apoptotic process
positive regulation of neuron apoptotic process
positive regulation of cell cycle
negative regulation of proteolysis
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
negative regulation of mitotic cell cycle
positive regulation of transcription from RNA polymerase II promoter
negative regulation of fibroblast proliferation
rhythmic process
circadian behavior
embryonic organ development
negative regulation of smooth muscle cell proliferation
positive regulation of peptidyl-tyrosine phosphorylation
regulation of catalytic activity
protein tetramerization
chromosome organization
neuron apoptotic process
regulation of intracellular pH
regulation of cell cycle
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
regulation of thymocyte apoptotic process
positive regulation of thymocyte apoptotic process
necroptotic process
positive regulation of cell cycle arrest
cellular response to ionizing radiation
cellular response to UV-C
mitotic cell cycle arrest
intrinsic apoptotic signaling pathway by p53 class mediator
regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter
positive regulation of release of cytochrome c from mitochondria
positive regulation of cell aging
replicative senescence
oxidative stress-induced premature senescence
oligodendrocyte apoptotic process
positive regulation of execution phase of apoptosis
negative regulation of macromitophagy
regulation of mitochondrial membrane permeability involved in apoptotic process
regulation of intrinsic apoptotic signaling pathway by p53 class mediator
regulation of hydrogen peroxide-induced cell death
negative regulation of glucose catabolic process to lactate via pyruvate
intrinsic apoptotic signaling pathway in response to hypoxia
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
regulation of fibroblast apoptotic process
negative regulation of DNA biosynthetic process
negative regulation of reactive oxygen species metabolic process
positive regulation of reactive oxygen species metabolic process
regulation of cellular senescence
positive regulation of intrinsic apoptotic signaling pathway

Function(s)

RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription factor binding
transcription cofactor binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
protease binding
p53 binding
DNA binding
chromatin binding
damaged DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
copper ion binding
protein binding
ATP binding
protein C-terminus binding
transcription factor binding
enzyme binding
protein kinase binding
protein phosphatase binding
receptor tyrosine kinase binding
ubiquitin protein ligase binding
histone deacetylase regulator activity
histone acetyltransferase binding
identical protein binding
sequence-specific DNA binding
protein self-association
transcription regulatory region DNA binding
metal ion binding
protein heterodimerization activity
protein N-terminus binding
chaperone binding
protein phosphatase 2A binding
MDM2/MDM4 family protein binding