1885

• Gene Symbol: SMO
• Gene Name: smoothened, frizzled class receptor
• Gene Aliases: FZD11, Gx, SMOH
• Chromosome Location: Chr.7: 129188872 - 129213548 on Build GRCh38
• UniGene ID: Hs.437846
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: SMO
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_005631.4	NP_005622.1	3	972
	XM_011516522.2	XP_011514824.1	4	538
GenBank mRNA	AF071494.1	-	3	692
	AF120103.1	-	3	750
	BC009989.2	-	3	972	4127774
	U84401.1	-	3	692

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Mouse: NM_176996, BC096028, BC048091, CN665198, FJ883552.

• Set Membership: G-protein coupled receptor

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
vasculogenesis
osteoblast differentiation
in utero embryonic development
cell fate specification
neural crest cell migration
heart looping
positive regulation of neuroblast proliferation
positive regulation of mesenchymal cell proliferation
determination of left/right asymmetry in lateral mesoderm
type B pancreatic cell development
G-protein coupled receptor signaling pathway
smoothened signaling pathway
positive regulation of hh target transcription factor activity
ventral midline determination
midgut development
anterior/posterior pattern specification
positive regulation of gene expression
negative regulation of gene expression
dentate gyrus development
cerebellar cortex morphogenesis
thalamus development
dorsal/ventral neural tube patterning
smoothened signaling pathway involved in ventral spinal cord patterning
smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
central nervous system neuron differentiation
cerebral cortex development
negative regulation of epithelial cell differentiation
hair follicle morphogenesis
protein localization to nucleus
multicellular organism growth
non-canonical Wnt signaling pathway
positive regulation of multicellular organism growth
positive regulation of protein import into nucleus
odontogenesis of dentin-containing tooth
negative regulation of apoptotic process
negative regulation of DNA binding
positive regulation of smoothened signaling pathway
positive regulation of transcription from RNA polymerase II promoter
positive regulation of organ growth
astrocyte activation
skeletal muscle fiber development
forebrain morphogenesis
homeostasis of number of cells within a tissue
positive regulation of epithelial cell proliferation
protein stabilization
myoblast migration
negative regulation of hair follicle development
canonical Wnt signaling pathway
detection of cell density by contact stimulus involved in contact inhibition
atrial septum morphogenesis
mammary gland epithelial cell differentiation
epithelial-mesenchymal cell signaling
somite development
pancreas morphogenesis
left/right axis specification
cellular response to cholesterol
renal system development
mesenchymal to epithelial transition involved in metanephric renal vesicle formation
positive regulation of branching involved in ureteric bud morphogenesis
regulation of stem cell population maintenance
regulation of heart morphogenesis

Function(s)

G-protein coupled receptor activity
patched binding
protein binding
drug binding
Wnt-protein binding
Wnt-activated receptor activity