188777

• Gene Symbol: Tlr4
• Gene Name: toll-like receptor 4
• Gene Aliases: Lps, Ly87, Ran/M1, Rasl2-8
• Chromosome Location: Chr.4: 66827811 - 66842797 on Build GRCm38
• UniGene ID: Mm.38049
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Tlr4
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_021297.2	NP_067272.1	3	2038
GenBank mRNA	AF095353.1	-	3	2224
	AF110133.1	-	3	2038
	AF185285.1	-	3	2017
	AK030348.1	-	3	2238
	AK154297.1	-	3	2131
	AK170566.1	-	3	2090
	BC029856.1	-	3	2250	3493732
	JX878358.1	-	3	2032
	JX878359.1	-	3	2032

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_019178, GQ175880, AF057025, FQ233814.

Gene Ontology Categories:

Process(es)

activation of MAPK activity
microglial cell activation
activation of innate immune response
toll-like receptor signaling pathway
B cell proliferation involved in immune response
immune system process
nitric oxide production involved in inflammatory response
regulation of dendritic cell cytokine production
MyD88-dependent toll-like receptor signaling pathway
innate immune response-activating signal transduction
leukotriene metabolic process
inflammatory response
response to oxidative stress
signal transduction
activation of NF-kappaB-inducing kinase activity
I-kappaB phosphorylation
response to bacterium
positive regulation of platelet activation
positive regulation of B cell proliferation
lipopolysaccharide-mediated signaling pathway
response to lipopolysaccharide
detection of lipopolysaccharide
interferon-gamma production
negative regulation of interferon-gamma production
negative regulation of interleukin-17 production
negative regulation of interleukin-23 production
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
positive regulation of chemokine production
positive regulation of interferon-alpha production
positive regulation of interferon-beta production
positive regulation of interferon-gamma production
positive regulation of interleukin-1 production
positive regulation of interleukin-10 production
positive regulation of interleukin-12 production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
positive regulation of tumor necrosis factor production
positive regulation of stress-activated MAPK cascade
toll-like receptor 4 signaling pathway
macrophage activation
positive regulation of NF-kappaB import into nucleus
positive regulation of tumor necrosis factor biosynthetic process
positive regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of DNA binding
positive regulation of interleukin-12 biosynthetic process
innate immune response
positive regulation of MHC class II biosynthetic process
positive regulation of interferon-beta biosynthetic process
positive regulation of interleukin-1 biosynthetic process
positive regulation of interleukin-13 biosynthetic process
positive regulation of interleukin-6 biosynthetic process
positive regulation of interleukin-8 biosynthetic process
positive regulation of nitric oxide biosynthetic process
response to ethanol
mast cell activation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
positive regulation of lymphocyte proliferation
regulation of cytokine secretion
regulation of inflammatory response
positive regulation of inflammatory response
positive regulation of peptidyl-tyrosine phosphorylation
defense response to Gram-negative bacterium
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
positive regulation of nitric-oxide synthase biosynthetic process
regulation of sensory perception of pain
intestinal epithelial structure maintenance
positive regulation of macrophage cytokine production
negative regulation of ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade
positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
response to fatty acid
cellular response to lipopolysaccharide
cellular response to lipoteichoic acid

Function(s)

lipopolysaccharide binding
lipopolysaccharide receptor activity
receptor activity
transmembrane signaling receptor activity
protein binding
phosphatidylinositol 3-kinase binding