189168

• Gene Symbol: Adam17
• Gene Name: ADAM metallopeptidase domain 17
• Gene Aliases: TACE
• Chromosome Location: Chr.6: 43400525 - 43448280 on Build Rnor_6.0
• UniGene ID: Rn.144585
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Adam17
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_020306.2	NP_064702.1	2	349
GenBank mRNA	AJ012603.1	-	2	351

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_003183, U86755, CN258241, U69612, AY422721, and others.
This siRNA also targets the following transcripts in Mouse: NM_001277266, NM_009615, BC138416, BC138420, U69613, and others.

Panther Classification:

Molecular Function -

protease

Gene Ontology Categories:

Process(es)

response to hypoxia
positive regulation of protein phosphorylation
germinal center formation
proteolysis
membrane protein ectodomain proteolysis
cell adhesion
epidermal growth factor receptor signaling pathway
Notch signaling pathway
Notch receptor processing
integrin-mediated signaling pathway
positive regulation of cell proliferation
positive regulation of T cell chemotaxis
B cell differentiation
positive regulation of cell growth
positive regulation of cell migration
positive regulation of transforming growth factor beta receptor signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
response to lipopolysaccharide
negative regulation of interleukin-8 production
positive regulation of chemokine production
regulation of mast cell apoptotic process
T cell differentiation in thymus
cell adhesion mediated by integrin
wound healing, spreading of epidermal cells
epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
response to drug
negative regulation of apoptotic process
positive regulation of epidermal growth factor-activated receptor activity
spleen development
cell motility
PMA-inducible membrane protein ectodomain proteolysis
positive regulation of cellular component movement
response to high density lipoprotein particle

Function(s)

metalloendopeptidase activity
Notch binding
interleukin-6 receptor binding
integrin binding
metallopeptidase activity
zinc ion binding
SH3 domain binding
PDZ domain binding