189259

• Gene Symbol: Top2a
• Gene Name: topoisomerase (DNA) II alpha
• Gene Aliases: -
• Chromosome Location: Chr.10: 86901467 - 86930947 on Build Rnor_6.0
• UniGene ID: Rn.90996
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Top2a
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_022183.2	NP_071519.2	1, 2	182
GenBank mRNA	Z19552.1	-	1, 2	182

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_001067, BC140791, AF285159, J04088, AF285158, and others.
This siRNA also targets the following transcripts in Mouse: NM_011623, D12513, BC057873.

Panther Classification:

Molecular Function -

DNA metabolism protein

Gene Ontology Categories:

Process(es)

resolution of meiotic recombination intermediates
sister chromatid segregation
hematopoietic progenitor cell differentiation
DNA topological change
DNA ligation
DNA unwinding involved in DNA replication
mitotic recombination
cellular response to DNA damage stimulus
chromosome segregation
brain development
aging
cerebellar Purkinje cell differentiation
cerebellar granule cell differentiation
chromosome condensation
apoptotic chromosome condensation
embryonic cleavage
response to drug
regulation of circadian rhythm
positive regulation of apoptotic process
mitotic DNA integrity checkpoint
positive regulation of viral genome replication
positive regulation of single stranded viral RNA replication via double stranded DNA intermediate
positive regulation of transcription from RNA polymerase II promoter
rhythmic process
response to parathyroid hormone

Function(s)

magnesium ion binding
DNA binding
chromatin binding
DNA topoisomerase activity
DNA topoisomerase type II (ATP-hydrolyzing) activity
protein kinase C binding
ATP binding
protein C-terminus binding
DNA-dependent ATPase activity
drug binding
DNA binding, bending
enzyme binding
protein homodimerization activity
histone deacetylase binding
ubiquitin binding
sequence-specific DNA binding
structure-specific DNA binding
poly(A) RNA binding
protein heterodimerization activity