190637

Gene Symbol:

Tnfsf11 LOC103689974

Gene Name:

tumor necrosis factor (ligand) superfamily, member 11

tumor necrosis factor ligand superfamily member 11

Gene Aliases:

RANKL

-

Chromosome Location:

Chr.15: 60482527 - 60512704 on Build Rnor_6.0

Chromosome Location:

Chr.15: 62066507 - 62097999 on Build Rnor_6.0

UniGene ID:

Rn.217570

-

Species:

Rat

Species Specific ID (Flybase ID):

-

-

siRNA Details

Gene Symbol: Tnfsf11
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_057149.1	NP_476490.1	5	620
GenBank mRNA	AF187319.1	-	5	620

Gene Symbol: LOC103689974
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	XM_008770928.1	XP_008769150.1	5	870

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Mouse: NM_011613, BC125603, AB032772, AF013170, AK159997, and others.

Gene Ontology Categories:

Process(es)

ossification
osteoclast proliferation
monocyte chemotaxis
immune response
activation of JUN kinase activity
multicellular organism development
response to radiation
organ morphogenesis
cytokine-mediated signaling pathway
cell differentiation
osteoclast differentiation
tumor necrosis factor-mediated signaling pathway
mammary gland epithelial cell proliferation
positive regulation of homotypic cell-cell adhesion
response to immobilization stress
positive regulation of phosphorylation
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAP kinase activity
bone resorption
regulation of osteoclast differentiation
positive regulation of osteoclast differentiation
positive regulation of bone resorption
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
positive regulation of T cell activation
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
protein homooligomerization
positive regulation of corticotropin-releasing hormone secretion
positive regulation of protein kinase B signaling
calcium ion homeostasis
mammary gland alveolus development
ERK1 and ERK2 cascade
positive regulation of fever generation by positive regulation of prostaglandin secretion
TNFSF11-mediated signaling pathway
positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling
positive regulation of intracellular signal transduction
positive regulation of osteoclast development

Function(s)

cytokine activity
tumor necrosis factor receptor binding
tumor necrosis factor receptor superfamily binding