192614

• Gene Symbol: Vegfa
• Gene Name: vascular endothelial growth factor A
• Gene Aliases: VEGF-A, VEGF164, VPF, Vegf
• Chromosome Location: Chr.9: 17340341 - 17355681 on Build Rnor_6.0
• UniGene ID: Rn.1923
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Vegfa
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001110335.1	NP_001103805.1	3	536
	NM_001287107.1	NP_001274036.1	6	1481
	NM_001287111.1	NP_001274040.1	6	1481
	NM_001287112.1	NP_001274041.1	6	1481
	NM_031836.3	NP_114024.2	6	1481
GenBank mRNA	AF062644.1	-	3	132
	AF215725.1	-	6	467
	AF222779.1	-	6	467
	AF261751.1	-	3	136
	AY033508.1	-	6	478
	CK357826.1	-	3	536
	CK364938.1	-	3	326
	EU040285.1	-	3	126
	L20913.1	-	4	351

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Mouse: NM_001110266, NM_001025250, BQ554097, S37052, AW913188, and others.

Panther Classification:

Molecular Function -

growth factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
angiogenesis
ovarian follicle development
blood vessel development
patterning of blood vessels
response to hypoxia
in utero embryonic development
kidney development
positive regulation of protein phosphorylation
positive regulation of endothelial cell proliferation
vasculature development
lymphangiogenesis
blood vessel remodeling
sprouting angiogenesis
cell migration involved in sprouting angiogenesis
positive regulation of neuroblast proliferation
positive regulation of mesenchymal cell proliferation
positive regulation of receptor internalization
basophil chemotaxis
heart morphogenesis
outflow tract morphogenesis
coronary vein morphogenesis
regulation of transcription from RNA polymerase II promoter
nervous system development
mesoderm development
female pregnancy
aging
lactation
cell proliferation
positive regulation of cell proliferation
regulation of cell shape
response to cold
positive regulation of signal transduction
positive regulation of endothelial cell migration
positive regulation of gene expression
cell migration
negative regulation of cell-cell adhesion
cell differentiation
hyaluronan metabolic process
monocyte differentiation
macrophage differentiation
lung development
positive regulation of cell migration
regulation of cGMP metabolic process
epithelial cell differentiation
positive regulation of vascular endothelial growth factor receptor signaling pathway
post-embryonic camera-type eye development
positive regulation of protein complex assembly
positive regulation of protein autophosphorylation
activation of protein kinase activity
response to estradiol
response to progesterone
positive regulation of CREB transcription factor activity
positive regulation of peptidyl-serine phosphorylation
response to vitamin A
tube formation
cellular response to drug
endothelial cell chemotaxis
cellular response to vascular endothelial growth factor stimulus
lymph vessel morphogenesis
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
vascular endothelial growth factor signaling pathway
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
VEGF-activated neuropilin signaling pathway
growth
wound healing
T-helper 1 type immune response
eye photoreceptor cell development
negative regulation of apoptotic process
negative regulation of programmed cell death
positive regulation of vascular permeability
surfactant homeostasis
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of MAP kinase activity
negative regulation of neuron apoptotic process
positive regulation of blood vessel endothelial cell migration
endothelial cell migration
cellular response to fibroblast growth factor stimulus
regulation of endothelial cell differentiation
positive regulation of angiogenesis
negative regulation of bone resorption
positive regulation of cell adhesion
positive regulation of transcription from RNA polymerase II promoter
vascular endothelial growth factor receptor signaling pathway
mRNA stabilization
lung alveolus development
cell maturation
blood vessel morphogenesis
camera-type eye morphogenesis
positive regulation of smooth muscle cell proliferation
neuron development
cardiac muscle fiber development
branching morphogenesis of an epithelial tube
positive regulation of axon extension involved in axon guidance
artery morphogenesis
positive regulation of epithelial cell proliferation
positive regulation of peptidyl-tyrosine phosphorylation
positive chemotaxis
positive regulation of positive chemotaxis
induction of positive chemotaxis
positive regulation of cellular component movement
response to folic acid
positive regulation of cell division
positive regulation of focal adhesion assembly
positive regulation of protein kinase B signaling
primitive erythrocyte differentiation
cell chemotaxis
lung vasculature development
mammary gland alveolus development
positive regulation of mast cell chemotaxis
cardiac vascular smooth muscle cell development
angiogenesis involved in coronary vascular morphogenesis
coronary artery morphogenesis
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
positive regulation of ERK1 and ERK2 cascade
response to oxygen levels
cellular response to hypoxia
dopaminergic neuron differentiation
response to dexamethasone
cellular response to dexamethasone stimulus
commissural neuron axon guidance
positive regulation of protein kinase C signaling
positive regulation of cell migration involved in sprouting angiogenesis
positive regulation of branching involved in ureteric bud morphogenesis
regulation of retinal ganglion cell axon guidance
positive regulation of peptidyl-tyrosine autophosphorylation
positive regulation of p38MAPK cascade
negative regulation of neuron death
positive regulation of lymphangiogenesis
regulation of hematopoietic progenitor cell differentiation
positive regulation of histone deacetylase activity
positive regulation of retinal ganglion cell axon guidance
positive regulation of protein localization to early endosome
positive regulation of protein kinase D signaling
negative regulation of extrinsic apoptotic signaling pathway

Function(s)

fibronectin binding
receptor binding
cytokine activity
platelet-derived growth factor receptor binding
vascular endothelial growth factor receptor binding
growth factor activity
heparin binding
neuropilin binding
chemoattractant activity
identical protein binding
protein homodimerization activity
vascular endothelial growth factor receptor 1 binding
vascular endothelial growth factor receptor 2 binding
protein heterodimerization activity
receptor agonist activity
extracellular matrix binding