193032

• Gene Symbol: Ptpn6
• Gene Name: protein tyrosine phosphatase, non-receptor type 6
• Gene Aliases: Ptph6, Shp-1
• Chromosome Location: Chr.4: 157239141 - 157263890 on Build Rnor_6.0
• UniGene ID: Rn.18985
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Ptpn6
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_053908.1	NP_446360.1	3	415
GenBank mRNA	U77038.1	-	3	415

More Information

Panther Classification:

Molecular Function -

protein phosphatase

Gene Ontology Categories:

Process(es)

hematopoietic progenitor cell differentiation
negative regulation of humoral immune response mediated by circulating immunoglobulin
protein dephosphorylation
cell proliferation
positive regulation of cell proliferation
response to wounding
positive regulation of phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
cell differentiation
platelet formation
abortive mitotic cell cycle
positive regulation of cell adhesion mediated by integrin
peptidyl-tyrosine dephosphorylation
intracellular signal transduction
megakaryocyte development
negative regulation of T cell proliferation
natural killer cell mediated cytotoxicity
negative regulation of MAP kinase activity
negative regulation of MAPK cascade
regulation of B cell differentiation
negative regulation of peptidyl-tyrosine phosphorylation
B cell receptor signaling pathway
negative regulation of B cell receptor signaling pathway
negative regulation of T cell receptor signaling pathway
regulation of release of sequestered calcium ion into cytosol
regulation of ERK1 and ERK2 cascade
platelet aggregation
regulation of G1/S transition of mitotic cell cycle

Function(s)

phosphotyrosine binding
protein tyrosine phosphatase activity
transmembrane receptor protein tyrosine phosphatase activity
SH3 domain binding
protein kinase binding
SH2 domain binding
natural killer cell lectin-like receptor binding