194428

• Gene Symbol: Tp63
• Gene Name: tumor protein p63
• Gene Aliases: Ket, P73l, Tp73l, Trp63
• Chromosome Location: Chr.11: 78234853 - 78456329 on Build Rnor_6.0
• UniGene ID: Rn.42907
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Tp63
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001127339.1	NP_001120811.1	2, 3	347
	NM_001127341.1	NP_001120813.1	2, 3	347
	NM_019221.3	NP_062094.1	2, 3	347
	XM_006248500.2	XP_006248562.1	2, 3	428
	XM_008768791.1	XP_008767013.1	3, 4	277
GenBank mRNA	AJ277446.1	-	1, 2	149
	AJ277448.1	-	1, 2	149
	AJ277449.1	-	2, 3	200
	AJ277451.1	-	2, 3	200
	AJ277452.1	-	1, 2	149
	Y10258.2	-	2, 3	347

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Mouse: NM_001127261, NM_001127259, NM_001127260, AF075435, AK138305, and others.

Panther Classification:

Molecular Function -

P53-like transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
replicative cell aging
skeletal system development
establishment of planar polarity
morphogenesis of a polarized epithelium
hair follicle development
positive regulation of mesenchymal cell proliferation
epithelial cell development
chromatin remodeling
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
apoptotic process
cellular response to DNA damage stimulus
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
Notch signaling pathway
spermatogenesis
pattern specification process
ectoderm and mesoderm interaction
cell aging
epidermis development
organ morphogenesis
proximal/distal pattern formation
response to X-ray
multicellular organism aging
response to gamma radiation
epidermal cell division
regulation of epidermal cell division
positive regulation of keratinocyte proliferation
cell differentiation
keratinocyte differentiation
embryonic limb morphogenesis
prostate gland development
epithelial cell differentiation
polarized epithelial cell differentiation
hair follicle morphogenesis
mitotic G1 DNA damage checkpoint
cellular response to UV
post-anal tail morphogenesis
odontogenesis of dentin-containing tooth
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
negative regulation of apoptotic process
regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of neuron apoptotic process
skin morphogenesis
keratinocyte proliferation
negative regulation of keratinocyte differentiation
positive regulation of osteoblast differentiation
positive regulation of Notch signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
sympathetic nervous system development
anatomical structure formation involved in morphogenesis
smooth muscle tissue development
female genitalia morphogenesis
protein tetramerization
protein homotetramerization
neuron apoptotic process
urinary bladder development
cloacal septation
prostatic bud formation
squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
establishment of skin barrier
positive regulation of cell cycle G1/S phase transition
regulation of nucleic acid-templated transcription
positive regulation of fibroblast apoptotic process
negative regulation of mesoderm development
negative regulation of cellular senescence
positive regulation of apoptotic signaling pathway

Function(s)

transcription factor activity, transcription factor binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
p53 binding
DNA binding
chromatin binding
damaged DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein domain specific binding
identical protein binding
sequence-specific DNA binding
transcription regulatory region DNA binding
metal ion binding
WW domain binding