194658

• Gene Symbol: Il12b
• Gene Name: interleukin 12B
• Gene Aliases: Il12
• Chromosome Location: Chr.10: 30034453 - 30048120 on Build Rnor_6.0
• UniGene ID: Rn.48686
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Il12b
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_022611.1	NP_072133.1	3	396
	XM_006246147.2	XP_006246209.1	4	605
GenBank mRNA	AF133197.1	-	3	396
	U16674.1	-	3	412

More Information

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

positive regulation of T cell mediated cytotoxicity
positive regulation of defense response to virus by host
natural killer cell activation involved in immune response
positive regulation of T-helper 1 type immune response
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
negative regulation of inflammatory response to antigenic stimulus
cell cycle arrest
cell surface receptor signaling pathway
response to UV-B
positive regulation of activation of JAK2 kinase activity
cell migration
cytokine-mediated signaling pathway
sensory perception of pain
natural killer cell activation
negative regulation of interleukin-10 production
negative regulation of interleukin-17 production
positive regulation of granulocyte macrophage colony-stimulating factor production
positive regulation of interferon-gamma production
positive regulation of interleukin-10 production
positive regulation of interleukin-12 production
positive regulation of interleukin-17 production
positive regulation of tumor necrosis factor production
positive regulation of natural killer cell activation
positive regulation of natural killer cell proliferation
positive regulation of mononuclear cell proliferation
positive regulation of smooth muscle cell apoptotic process
T-helper cell differentiation
positive regulation of T cell proliferation
positive regulation of activated T cell proliferation
regulation of tyrosine phosphorylation of Stat1 protein
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of tyrosine phosphorylation of Stat4 protein
positive regulation of tyrosine phosphorylation of Stat5 protein
defense response to protozoan
negative regulation of growth of symbiont in host
positive regulation of osteoclast differentiation
positive regulation of cell adhesion
negative regulation of smooth muscle cell proliferation
positive regulation of lymphocyte proliferation
defense response to Gram-negative bacterium
positive regulation of NK T cell activation
positive regulation of NK T cell proliferation
defense response to virus
cellular response to lipopolysaccharide
cellular response to interferon-gamma

Function(s)

cytokine receptor activity
cytokine activity
cytokine receptor binding
growth factor activity
interleukin-12 alpha subunit binding
identical protein binding
protein homodimerization activity
interleukin-23 receptor binding
protein heterodimerization activity