196543

Gene Symbol:

LOC690182 Egln1

Gene Name:

similar to Egl nine homolog 1 (Hypoxia-inducible factor prolyl hydroxylase 2) (HIF-prolyl hydroxylase 2) (HIF-PH2) (HPH-2) (SM-20)

egl-9 family hypoxia-inducible factor 1

Gene Aliases:

-

HIF-PH2, HPH-2, PHD-2, PHD2

Chromosome Location:

Chr.1: 173283884 - 173291061 on Build Rnor_6.0

Chromosome Location:

Chr.19: 57660194 - 57701158 on Build Rnor_6.0

UniGene ID:

-

Rn.232203

Species:

Rat

Species Specific ID (Flybase ID):

-

-

siRNA Details

Gene Symbol: LOC690182
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	XM_008759848.1	XP_008758070.1	1	503

Gene Symbol: Egln1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	XM_008772679.1	XP_008770901.1	3	1478
GenBank mRNA	AY228140.1	-	1	263
	BC081694.1	-	1	507

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Mouse: NM_053207, BC083146, AJ310546, AF453878.

Gene Ontology Categories:

Process(es)

response to hypoxia
peptidyl-proline hydroxylation to 4-hydroxy-L-proline
negative regulation of cAMP catabolic process
oxygen homeostasis
negative regulation of sequence-specific DNA binding transcription factor activity
regulation of angiogenesis
negative regulation of cyclic-nucleotide phosphodiesterase activity
cardiac muscle tissue morphogenesis
oxidation-reduction process
heart trabecula formation
ventricular septum morphogenesis
labyrinthine layer development
response to nitric oxide

Function(s)

iron ion binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
enzyme binding
L-ascorbic acid binding
peptidyl-proline dioxygenase activity
peptidyl-proline 4-dioxygenase activity