197699

• Gene Symbol: Ptk2
• Gene Name: protein tyrosine kinase 2
• Gene Aliases: FAK, FRNK, p125FAK
• Chromosome Location: Chr.7: 114436419 - 114611334 on Build Rnor_6.0
• UniGene ID: Rn.2809
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Ptk2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_013081.2	NP_037213.1	4	845
	XM_008765546.1	XP_008763768.1	6	974
GenBank mRNA	AF020777.1	-	4	844

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_001199649, NM_005607, NM_153831, BC035404, AB209083, and others.
This siRNA also targets the following transcripts in Mouse: NM_001130409, NM_007982, AK079821, AB030035, AB011499, and others.

Gene Ontology Categories:

Process(es)

MAPK cascade
microtubule cytoskeleton organization
angiogenesis
blood vessel development
vasculogenesis
neuron migration
positive regulation of protein phosphorylation
cytoskeleton organization
signal complex assembly
epidermal growth factor receptor signaling pathway
transforming growth factor beta receptor signaling pathway
integrin-mediated signaling pathway
JNK cascade
positive regulation of cell proliferation
regulation of cell shape
response to mechanical stimulus
response to glucose
response to organic substance
response to organonitrogen compound
positive regulation of phosphatidylinositol 3-kinase signaling
response to organic cyclic compound
positive regulation of smooth muscle cell migration
peptidyl-tyrosine phosphorylation
central nervous system neuron axonogenesis
negative regulation of cell-cell adhesion
extracellular matrix organization
positive regulation of cell growth
positive regulation of cell migration
negative regulation of cell migration
cellular chloride ion homeostasis
response to estradiol
regulation of cell adhesion mediated by integrin
peptidyl-tyrosine autophosphorylation
establishment of nucleus localization
regulation of cell proliferation
response to drug
negative regulation of apoptotic process
endothelial cell migration
innate immune response
fat cell differentiation
regulation of osteoblast differentiation
positive regulation of cell adhesion
positive regulation of protein kinase activity
positive regulation of vasodilation
negative regulation of organ growth
response to arsenic-containing substance
protein autophosphorylation
ephrin receptor signaling pathway
positive regulation of smooth muscle cell proliferation
positive regulation of phagocytosis
negative regulation of axonogenesis
positive regulation of synaptic transmission
positive regulation of protein kinase B signaling
negative regulation of synapse assembly
positive regulation of glial cell proliferation
growth hormone receptor signaling pathway
cellular response to transforming growth factor beta stimulus
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of anoikis

Function(s)

actin binding
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
signal transducer activity
integrin binding
protein binding
ATP binding
JUN kinase binding
protein kinase binding
protein complex binding
SH2 domain binding
identical protein binding
phosphatidylinositol 3-kinase binding