197717

• Gene Symbol: Ptpn11
• Gene Name: protein tyrosine phosphatase, non-receptor type 11
• Gene Aliases: Shp2
• Chromosome Location: Chr.12: 40895515 - 40955999 on Build Rnor_6.0
• UniGene ID: Rn.98209
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Ptpn11
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001177593.1	NP_001171064.1	9	1131
	NM_013088.2	NP_037220.2	9	1131
GenBank mRNA	D83016.1	-	3	180
	U05963.1	-	9	1062
	U09307.1	-	9	1056
	U57499.1	-	1	35

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_080601, NM_002834, L07527, D13540, BT007106, and others.

Panther Classification:

Molecular Function -

protein phosphatase

Gene Ontology Categories:

Process(es)

DNA damage checkpoint
activation of MAPK activity
protein dephosphorylation
lipid metabolic process
triglyceride metabolic process
epidermal growth factor receptor signaling pathway
integrin-mediated signaling pathway
axonogenesis
brain development
heart development
hormone-mediated signaling pathway
positive regulation of signal transduction
dephosphorylation
platelet formation
microvillus organization
abortive mitotic cell cycle
regulation of cell adhesion mediated by integrin
negative regulation of cell adhesion mediated by integrin
multicellular organism growth
organ growth
peptidyl-tyrosine dephosphorylation
megakaryocyte development
atrioventricular canal development
ERBB signaling pathway
regulation of multicellular organism growth
hormone metabolic process
glucose homeostasis
positive regulation of mitotic cell cycle
negative regulation of insulin secretion
regulation of protein export from nucleus
positive regulation of hormone secretion
negative regulation of hormone secretion
platelet-derived growth factor receptor signaling pathway
neurotrophin TRK receptor signaling pathway
ephrin receptor signaling pathway
multicellular organismal reproductive process
genitalia development
inner ear development
homeostasis of number of cells within a tissue
negative regulation of cortisol secretion
negative regulation of growth hormone secretion
face morphogenesis
intestinal epithelial cell migration
positive regulation of ERK1 and ERK2 cascade
positive regulation of glucose import in response to insulin stimulus

Function(s)

phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
non-membrane spanning protein tyrosine phosphatase activity
SH3/SH2 adaptor activity
insulin receptor binding
protein binding
protein domain specific binding
receptor tyrosine kinase binding
D1 dopamine receptor binding
phospholipase binding
insulin receptor substrate binding
peptide hormone receptor binding