197733

• Gene Symbol: Smad3
• Gene Name: SMAD family member 3
• Gene Aliases: Madh3, Smad 3, mad3
• Chromosome Location: Chr.8: 68569530 - 68678349 on Build Rnor_6.0
• UniGene ID: Rn.10636
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Smad3
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_013095.3	NP_037227.1	5, 6	853
	XM_008766216.1	XP_008764438.1	3, 4	792
	XM_008766217.1	XP_008764439.1	3, 4	518
GenBank mRNA	BC064437.1	-		853	5599910
	DQ409172.1	-	2, 3	109
	U66479.1	-	5, 6	662

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Mouse: NM_016769, AK041743, AK048626, AF016189, AB008192, and others.

Panther Classification:

Molecular Function -

DNA-binding transcription factor, gene-specific transcriptional regulator

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
skeletal system development
osteoblast differentiation
ureteric bud development
response to hypoxia
in utero embryonic development
mesoderm formation
somitogenesis
liver development
negative regulation of protein phosphorylation
heart looping
osteoblast development
immune system development
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transport
activation of cysteine-type endopeptidase activity involved in apoptotic process
immune response
cell cycle arrest
transforming growth factor beta receptor signaling pathway
SMAD protein complex assembly
gastrulation
endoderm development
negative regulation of cell proliferation
embryonic pattern specification
positive regulation of gene expression
positive regulation of alkaline phosphatase activity
positive regulation of epithelial to mesenchymal transition
regulation of striated muscle tissue development
regulation of transforming growth factor beta receptor signaling pathway
evasion or tolerance of host defenses by virus
signal transduction involved in regulation of gene expression
negative regulation of cell growth
positive regulation of cell migration
positive regulation of bone mineralization
thyroid gland development
positive regulation of chondrocyte differentiation
positive regulation of interleukin-1 beta production
regulation of transforming growth factor beta2 production
positive regulation of transforming growth factor beta3 production
activin receptor signaling pathway
negative regulation of osteoblast proliferation
positive regulation of catenin import into nucleus
intracellular signal transduction
nodal signaling pathway
T cell activation
negative regulation of protein catabolic process
positive regulation of transcription factor import into nucleus
negative regulation of apoptotic process
cell-cell junction organization
negative regulation of osteoblast differentiation
positive regulation of transcription, DNA-templated
negative regulation of mitotic cell cycle
positive regulation of transcription from RNA polymerase II promoter
paraxial mesoderm morphogenesis
developmental growth
embryonic foregut morphogenesis
embryonic cranial skeleton morphogenesis
regulation of epithelial cell proliferation
negative regulation of inflammatory response
regulation of immune response
protein stabilization
positive regulation of positive chemotaxis
regulation of binding
positive regulation of stress fiber assembly
positive regulation of focal adhesion assembly
pericardium development
transdifferentiation
SMAD protein signal transduction
negative regulation of wound healing
lens fiber cell differentiation
positive regulation of canonical Wnt signaling pathway
extrinsic apoptotic signaling pathway
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
positive regulation of extracellular matrix assembly

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter sequence-specific
core promoter proximal region sequence-specific DNA binding
RNA polymerase II activating transcription factor binding
DNA binding
chromatin binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
transforming growth factor beta receptor binding
protein binding
collagen binding
beta-catenin binding
transcription factor binding
zinc ion binding
enzyme binding
protein kinase binding
phosphatase binding
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
chromatin DNA binding
ubiquitin protein ligase binding
identical protein binding
protein homodimerization activity
ubiquitin binding
bHLH transcription factor binding
sequence-specific DNA binding
transcription regulatory region DNA binding
SMAD binding
protein heterodimerization activity
co-SMAD binding
R-SMAD binding