198668

• Gene Symbol: Tlr4
• Gene Name: toll-like receptor 4
• Gene Aliases: -
• Chromosome Location: Chr.5: 82587424 - 82601056 on Build Rnor_6.0
• UniGene ID: Rn.14534
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Tlr4
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_019178.1	NP_062051.1	2	454
GenBank mRNA	AF057025.1	-	2	476
	EU929065.1	-	2	179

More Information

Gene Ontology Categories:

Process(es)

activation of MAPK activity
response to hypoxia
microglial cell activation
activation of innate immune response
toll-like receptor signaling pathway
B cell proliferation involved in immune response
nitric oxide production involved in inflammatory response
MyD88-dependent toll-like receptor signaling pathway
innate immune response-activating signal transduction
skeletal muscle contraction
leukotriene metabolic process
inflammatory response
response to oxidative stress
I-kappaB phosphorylation
response to bacterium
response to toxic substance
positive regulation of platelet activation
response to activity
immunoglobulin mediated immune response
positive regulation of B cell proliferation
lipopolysaccharide-mediated signaling pathway
response to lipopolysaccharide
detection of lipopolysaccharide
response to retinoic acid
response to progesterone
interferon-gamma production
negative regulation of interferon-gamma production
negative regulation of interleukin-17 production
negative regulation of interleukin-23 production
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
positive regulation of chemokine production
positive regulation of interferon-alpha production
positive regulation of interferon-beta production
positive regulation of interferon-gamma production
positive regulation of interleukin-1 production
positive regulation of interleukin-10 production
positive regulation of interleukin-12 production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
positive regulation of tumor necrosis factor production
response to insulin
positive regulation of stress-activated MAPK cascade
toll-like receptor 4 signaling pathway
macrophage activation
positive regulation of NF-kappaB import into nucleus
positive regulation of tumor necrosis factor biosynthetic process
positive regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
response to morphine
positive regulation of DNA binding
positive regulation of interleukin-12 biosynthetic process
innate immune response
positive regulation of MHC class II biosynthetic process
positive regulation of interferon-beta biosynthetic process
positive regulation of interleukin-8 biosynthetic process
positive regulation of nitric oxide biosynthetic process
response to ethanol
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
positive regulation of lymphocyte proliferation
regulation of cytokine secretion
regulation of inflammatory response
positive regulation of inflammatory response
positive regulation of peptidyl-tyrosine phosphorylation
defense response to Gram-negative bacterium
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
response to glucocorticoid
positive regulation of nitric-oxide synthase biosynthetic process
regulation of sensory perception of pain
intestinal epithelial structure maintenance
positive regulation of macrophage cytokine production
negative regulation of ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade
positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
response to fatty acid
cellular response to lipopolysaccharide
cellular response to lipoteichoic acid
cellular response to mechanical stimulus
cellular response to retinoic acid
response to gold nanoparticle

Function(s)

lipopolysaccharide binding
lipopolysaccharide receptor activity
receptor activity
transmembrane signaling receptor activity
protein binding
phosphatidylinositol 3-kinase binding