199318

• Gene Symbol: Hif1a
• Gene Name: hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
• Gene Aliases: MOP1
• Chromosome Location: Chr.6: 96810872 - 96856307 on Build Rnor_6.0
• UniGene ID: Rn.10852
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Hif1a
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_024359.1	NP_077335.1	2	151
	XM_006240196.2	XP_006240258.1	2	464
	XM_006240197.2	XP_006240259.1	2	461
	XM_006240198.2	XP_006240260.1	2	460
	XM_006240199.2	XP_006240261.1	2	163
	XM_008764695.1	XP_008762917.1	2	248
GenBank mRNA	AF057308.1	-	2	151
	Y09507.1	-	2	248

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_001243084, NM_001530, NM_181054, U22431, BX648795, and others.
This siRNA also targets the following transcripts in Mouse: NM_010431, BC026139, BY725437, AK034087, AK138944, and others.

Panther Classification:

Molecular Function -

basic helix-loop-helix transcription factor

Gene Ontology Categories:

Process(es)

angiogenesis
blood vessel development
response to hypoxia
neural crest cell migration
epithelial to mesenchymal transition
embryonic placenta development
B-1 B cell homeostasis
vasculature development
heart looping
positive regulation of neuroblast proliferation
connective tissue replacement involved in inflammatory response wound healing
outflow tract morphogenesis
cardiac ventricle morphogenesis
lactate metabolic process
regulation of glycolytic process
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
cellular iron ion homeostasis
signal transduction
lactation
positive regulation of cell proliferation
visual learning
response to mechanical stimulus
response to salt stress
response to glucose
response to X-ray
regulation of gene expression
vascular endothelial growth factor production
positive regulation of vascular endothelial growth factor production
positive regulation of gene expression
positive regulation of epithelial cell migration
positive regulation of receptor biosynthetic process
response to auditory stimulus
response to purine-containing compound
response to activity
response to muscle activity
axonal transport of mitochondrion
neural fold elevation formation
cerebral cortex development
cell differentiation
negative regulation of bone mineralization
positive regulation of vascular endothelial growth factor receptor signaling pathway
negative regulation of TOR signaling
response to cobalt ion
response to estradiol
oxygen homeostasis
cellular response to insulin stimulus
regulation of transforming growth factor beta2 production
collagen metabolic process
negative regulation of transcription elongation from RNA polymerase II promoter
embryonic hemopoiesis
cellular response to drug
positive regulation of insulin secretion involved in cellular response to glucose stimulus
regulation of cell proliferation
response to drug
hemoglobin biosynthetic process
glucose homeostasis
positive regulation of apoptotic process
negative regulation of apoptotic process
response to alkaloid
negative regulation of neuron apoptotic process
regulation of transcription from RNA polymerase II promoter in response to oxidative stress
response to estrogen
positive regulation of erythrocyte differentiation
positive regulation of cell size
positive regulation of transcription, DNA-templated
negative regulation of vasoconstriction
negative regulation of growth
positive regulation of transcription from RNA polymerase II promoter
muscle cell cellular homeostasis
positive regulation of hormone biosynthetic process
blood vessel morphogenesis
digestive tract morphogenesis
positive regulation of smooth muscle cell proliferation
regulation of catalytic activity
cartilage development
response to glucocorticoid
elastin metabolic process
maternal process involved in female pregnancy
intestinal epithelial cell maturation
response to fungicide
epithelial cell differentiation involved in mammary gland alveolus development
retina vasculature development in camera-type eye
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
regulation of thymocyte apoptotic process
negative regulation of thymocyte apoptotic process
cellular response to hydrogen peroxide
cellular response to lipopolysaccharide
cellular response to carbon monoxide
cellular response to nitrite
cellular response to electrical stimulus
cellular response to mechanical stimulus
cellular response to cobalt ion
cellular response to glucose stimulus
cellular response to interleukin-1
cellular response to lipid
cellular response to organic cyclic compound
cellular response to hypoxia
cellular response to light stimulus
dopaminergic neuron differentiation
response to anesthetic
cellular response to toxic substance
hypoxia-inducible factor-1alpha signaling pathway
regulation of cellular response to hypoxia
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
cellular response to cyanide
negative regulation of mesenchymal cell apoptotic process

Function(s)

transcription factor activity, transcription factor binding
transcription factor activity, RNA polymerase II transcription factor binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
signal transducer activity
protein binding
transcription factor binding
enzyme binding
protein kinase binding
ubiquitin protein ligase binding
protein complex binding
histone acetyltransferase binding
nuclear hormone receptor binding
histone deacetylase binding
sequence-specific DNA binding
protein heterodimerization activity
Hsp90 protein binding