200499

• Gene Symbol: Gclc
• Gene Name: glutamate-cysteine ligase, catalytic subunit
• Gene Aliases: Glclc
• Chromosome Location: Chr.8: 85059051 - 85097471 on Build Rnor_6.0
• UniGene ID: Rn.8365
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Gclc
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_012815.2	NP_036947.1	10, 11	1259
GenBank mRNA	BC081702.1	-	10, 11	1259	7110739
	J05181.1	-	10, 11	1231

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_001498, NM_001197115, AB262176, BC039894, M90656, and others.
This siRNA also targets the following transcripts in Mouse: NM_010295, U85414, AK160876, AK144339, AK169676, and others.

Panther Classification:

Molecular Function -

ligase

Gene Ontology Categories:

Process(es)

cysteine metabolic process
glutamate metabolic process
glutathione metabolic process
glutathione biosynthetic process
response to oxidative stress
apoptotic mitochondrial changes
response to heat
response to xenobiotic stimulus
response to hormone
L-ascorbic acid metabolic process
negative regulation of protein ubiquitination
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
cell redox homeostasis
negative regulation of transcription, DNA-templated
response to arsenic-containing substance
regulation of blood vessel size
response to nitrosative stress
regulation of mitochondrial depolarization
negative regulation of extrinsic apoptotic signaling pathway

Function(s)

magnesium ion binding
glutamate-cysteine ligase activity
ATP binding
glutamate binding
ADP binding
protein heterodimerization activity
coenzyme binding