201421

• Gene Symbol: Dab2ip
• Gene Name: DAB2 interacting protein
• Gene Aliases: AIP-1, DIP1/2
• Chromosome Location: Chr.3: 14889263 - 15060286 on Build Rnor_6.0
• UniGene ID: Rn.14323
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Dab2ip
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_138710.3	NP_619724.3	16	6366
	XM_006234057.2	XP_006234119.1	15	6353
	XM_008761697.1	XP_008759919.1	13	6764
	XM_008761698.1	XP_008759920.1	13	6698
	XM_008761699.1	XP_008759921.1	14	5793
GenBank mRNA	AF236130.1	-	16	5989
	BC061865.1	-	12	5680	5598046
	FQ230253.1	-	1	722

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Mouse: NM_001114124, NM_001114125, NM_001001602, AY305657, AY178784, and others.

Panther Classification:

Molecular Function -

GTPase-activating protein

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
activation of MAPKKK activity
angiogenesis
negative regulation of protein phosphorylation
apoptotic process
response to unfolded protein
I-kappaB phosphorylation
activation of JUN kinase activity
negative regulation of cell proliferation
extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of endothelial cell migration
negative regulation of epithelial cell migration
negative regulation of epithelial to mesenchymal transition
positive regulation of neuron projection development
negative regulation of phosphatidylinositol 3-kinase signaling
negative regulation of angiogenesis
cell motility involved in cerebral cortex radial glia guided migration
layer formation in cerebral cortex
negative regulation of cell growth
negative regulation of vascular endothelial growth factor receptor signaling pathway
negative regulation of NF-kappaB transcription factor activity
negative regulation of toll-like receptor 4 signaling pathway
negative regulation of GTPase activity
tube formation
negative regulation of catenin import into nucleus
cellular response to vascular endothelial growth factor stimulus
vascular endothelial growth factor receptor-2 signaling pathway
reelin-mediated signaling pathway
negative regulation of epidermal growth factor receptor signaling pathway
positive regulation of apoptotic process
regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
regulation of protein complex assembly
negative regulation of MAP kinase activity
positive regulation of MAPK cascade
regulation of protein heterodimerization activity
positive regulation of JUN kinase activity
negative regulation of phosphatidylinositol 3-kinase activity
cellular protein catabolic process
positive regulation of protein catabolic process
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
negative regulation of Ras protein signal transduction
negative regulation of fibroblast proliferation
neuron projection morphogenesis
positive regulation of epithelial cell proliferation
negative regulation of epithelial cell proliferation
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
negative regulation of G0 to G1 transition
negative regulation of ERK1 and ERK2 cascade
positive regulation of cell cycle arrest
cellular response to lipopolysaccharide
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to epidermal growth factor stimulus
negative regulation of protein serine/threonine kinase activity
positive regulation of protein serine/threonine kinase activity
negative regulation of canonical Wnt signaling pathway
positive regulation of synapse maturation
positive regulation of dendrite development
regulation of p38MAPK cascade
negative regulation of vascular endothelial growth factor signaling pathway
positive regulation of proteasomal protein catabolic process
negative regulation of cyclin catabolic process
positive regulation of neuron migration
positive regulation of apoptotic signaling pathway

Function(s)

GTPase activator activity
death receptor binding
protein binding
SH3 domain binding
kinase binding
protein kinase binding
mitogen-activated protein kinase kinase binding
mitogen-activated protein kinase kinase kinase binding
phosphatidylinositol-3-phosphate binding
protein complex binding
signaling adaptor activity
Toll-like receptor 4 binding
phosphatidylinositol 3-kinase regulatory subunit binding
identical protein binding
protein homodimerization activity
vascular endothelial growth factor receptor 2 binding
phosphatidylinositol 3-kinase binding
protein N-terminus binding
protein phosphatase 2A binding
phosphatidylinositol-4-phosphate binding
14-3-3 protein binding