201749

• Gene Symbol: Pcsk9
• Gene Name: proprotein convertase subtilisin/kexin type 9
• Gene Aliases: NARC-1, Narc1, PC9
• Chromosome Location: Chr.5: 126031368 - 126053726 on Build Rnor_6.0
• UniGene ID: Rn.19195
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Pcsk9
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_199253.2	NP_954862.2	11	2008
GenBank mRNA	AY847775.1	-	11	2008
	BC133063.1	-	11	1939	8371686
	FQ219599.1	-	2	236

More Information

Panther Classification:

Molecular Function -

serine protease

Gene Ontology Categories:

Process(es)

kidney development
liver development
negative regulation of receptor recycling
positive regulation of receptor internalization
proteolysis
triglyceride metabolic process
phospholipid metabolic process
apoptotic process
lysosomal transport
cholesterol metabolic process
cellular response to starvation
regulation of receptor activity
negative regulation of low-density lipoprotein particle clearance
protein processing
protein autoprocessing
neurogenesis
neuron differentiation
low-density lipoprotein receptor particle metabolic process
low-density lipoprotein particle receptor catabolic process
regulation of low-density lipoprotein particle receptor catabolic process
cellular response to insulin stimulus
lipoprotein metabolic process
cholesterol homeostasis
regulation of neuron apoptotic process
positive regulation of neuron apoptotic process

Function(s)

serine-type endopeptidase activity
sodium channel inhibitor activity
low-density lipoprotein particle binding
apolipoprotein binding
very-low-density lipoprotein particle binding
apolipoprotein receptor binding
protein self-association
poly(A) RNA binding
low-density lipoprotein particle receptor binding
very-low-density lipoprotein particle receptor binding