202031

• Gene Symbol: ESR2
• Gene Name: estrogen receptor 2
• Gene Aliases: ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2
• Chromosome Location: Chr.14: 64226712 - 64338631 on Build GRCh38
• UniGene ID: Hs.660607
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: ESR2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001040275.1	NP_001035365.1	3, 4	1003
	NM_001214902.1	NP_001201831.1	2, 3	625
	NM_001271876.1	NP_001258805.1	2, 3	625
	NM_001271877.1	NP_001258806.1	2, 3	625
	NM_001291712.1	NP_001278641.1	8, 9	2263
	NM_001291723.1	NP_001278652.1	3, 4	1278
	NM_001437.2	NP_001428.1	3, 4	1003
	NR_073496.1		3, 4	1278
	XM_017021079.1	XP_016876568.1	4, 5	1667
	XM_017021080.1	XP_016876569.1	4, 5	2476
	XM_017021081.1	XP_016876570.1	4, 5	1572
	XM_017021082.1	XP_016876571.1	4, 5	1424
	XM_017021083.1	XP_016876572.1	3, 4	841
	XM_017021084.1	XP_016876573.1	4, 5	1667
GenBank mRNA	AB006589.1	-	8, 9	1810
	AB006590.1	-	2, 3	633
	AB209620.1	-	2, 3	631
	AF051427.1	-	3, 4	953
	AF051428.1	-	3, 4	953
	AF060555.1	-	3, 4	1005
	AF074599.1	-	2, 3	363
	AF124790.1	-	2, 3	586
	AK292370.1	-	3, 4	840
	BC024181.2	-	3, 4	820	4825937
	DQ777076.1	-	2, 3	535
	DQ777077.1	-	2, 3	535
	DQ838582.1	-	2, 3	535
	DQ838583.1	-	2, 3	535
	HQ692820.1	-	2, 3	535
	HQ692821.1	-	2, 3	535
	KJ534833.1	-	2, 3	535
	X99101.1	-	2, 3	394

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_012689, NM_012754, XM_006227832, XM_008758704, XM_006240221, and others.
This siRNA also targets the following transcripts in Mouse: NM_010157, NM_207707, U81451, AK054290, AK054301, and others.

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
ovarian follicle development
behavioral fear response
regulation of transcription, DNA-templated
transcription initiation from RNA polymerase II promoter
signal transduction
cell-cell signaling
learning or memory
response to water deprivation
response to activity
response to insecticide
cerebellum development
amygdala development
hypothalamus development
negative regulation of cell growth
intracellular estrogen receptor signaling pathway
prostate gland development
response to nutrient levels
response to testosterone
response to genistein
cellular response to drug
positive regulation of apoptotic process
regulation of neuron apoptotic process
response to estrogen
response to human chorionic gonadotropin
estrous cycle
response to ethanol
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of transcription, DNA-templated
positive regulation of vasodilation
positive regulation of transcription from RNA polymerase II promoter
negative regulation of smooth muscle cell proliferation
negative regulation of epithelial cell proliferation
positive regulation of sequence-specific DNA binding transcription factor activity
Sertoli cell development
Sertoli cell proliferation
positive regulation of ERK1 and ERK2 cascade
cellular response to magnetism
cellular response to estradiol stimulus
response to dexamethasone
extracellular negative regulation of signal transduction
negative regulation of neuron death
response to salt
response to bisphenol A
negative regulation of feeding behavior
negative regulation of reactive oxygen species metabolic process

Function(s)

core promoter sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
transcription coactivator activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
steroid binding
protein binding
drug binding
zinc ion binding
enzyme binding
estrogen receptor activity
estrogen response element binding
RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
peroxisome proliferator activated receptor binding
receptor antagonist activity
estradiol binding
steroid hormone binding