20435

• Gene Symbol: GREM1
• Gene Name: gremlin 1, DAN family BMP antagonist
• Gene Aliases: C15DUPq, CKTSF1B1, CRAC1, CRCS4, DAND2, DRM, DUP15q, GREMLIN, HMPS, HMPS1, IHG-2, MPSH, PIG2
• Chromosome Location: Chr.15: 32717940 - 32734669 on Build GRCh38
• UniGene ID: Hs.40098
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: GREM1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001191323.1	NP_001178252.1	2	237
	NM_013372.6	NP_037504.1	2	237
	XM_005254301.2	XP_005254358.1	2	301
	XM_017022077.1	XP_016877566.1	2	283
GenBank mRNA	AF045800.1	-	1	78
	AF110137.2	-	2	140
	AF154054.1	-	2	207
	AK095890.1	-	2	237
	AK312265.1	-	2	238
	AY232290.1	-	2	213
	BC069525.1	-	1	78	7262108
	BC093778.1	-	2	100	7939623
	BC101611.1	-	2	100	8069117

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_019282, Y10019.

Gene Ontology Categories:

Process(es)

cell morphogenesis
branching involved in ureteric bud morphogenesis
cell migration involved in sprouting angiogenesis
positive regulation of receptor internalization
positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
mesenchymal to epithelial transition involved in metanephros morphogenesis
apoptotic process
signal transduction
activation of transmembrane receptor protein tyrosine kinase activity
cell-cell signaling
positive regulation of cell proliferation
proximal/distal pattern formation
regulation of epithelial to mesenchymal transition
collagen fibril organization
negative regulation of cell growth
embryonic limb morphogenesis
negative regulation of bone mineralization
negative regulation of BMP signaling pathway
negative regulation of chondrocyte differentiation
regulation of stress-activated MAPK cascade
negative regulation of osteoblast proliferation
positive regulation of NF-kappaB import into nucleus
negative regulation of apoptotic process
positive regulation of angiogenesis
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of bone remodeling
determination of dorsal identity
positive regulation of NF-kappaB transcription factor activity
regulation of focal adhesion assembly
positive regulation of telomerase activity
limb development
negative regulation of pathway-restricted SMAD protein phosphorylation
ureteric bud formation
positive regulation of protein tyrosine kinase activity
signal transduction by p53 class mediator
negative regulation of monocyte chemotaxis
negative regulation of canonical Wnt signaling pathway
positive regulation of branching involved in ureteric bud morphogenesis
negative regulation of branching involved in ureteric bud morphogenesis
negative regulation of osteoclast proliferation
positive regulation of peptidyl-tyrosine autophosphorylation
negative regulation of bone trabecula formation
negative regulation of bone mineralization involved in bone maturation
positive regulation of receptor activity
positive regulation of cardiac muscle cell differentiation

Function(s)

cytokine activity
protein binding
morphogen activity
transmembrane receptor protein tyrosine kinase activator activity
BMP binding
vascular endothelial growth factor receptor 2 binding
receptor agonist activity