212894

• Gene Symbol: PTPN1
• Gene Name: protein tyrosine phosphatase, non-receptor type 1
• Gene Aliases: PTP1B
• Chromosome Location: Chr.20: 50510321 - 50584762 on Build GRCh38
• UniGene ID: Hs.417549
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: PTPN1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_002827.3	NP_002818.1	2	323
GenBank mRNA	AK290638.1	-	2	290
	AK316563.1	-	2	265
	AU117677.1	-	2	290
	BC015660.2	-	2	252	4844022
	BC018164.1	-	2	233	4338750
	BT006752.1	-	2	116
	DC300354.1	-	2	323
	M31724.1	-	2	206
	M33689.1	-	2	188

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Mouse: NM_011201, AK166020, AK150322, AK165949, AK153088, and others.

Panther Classification:

Molecular Function -

protein phosphatase

Gene Ontology Categories:

Process(es)

protein dephosphorylation
activation of signaling protein activity involved in unfolded protein response
activation of JUN kinase activity
insulin receptor signaling pathway
regulation of signal transduction
negative regulation of signal transduction
regulation of endocytosis
negative regulation of vascular endothelial growth factor receptor signaling pathway
endoplasmic reticulum unfolded protein response
actin cytoskeleton reorganization
regulation of intracellular protein transport
peptidyl-tyrosine dephosphorylation
platelet-derived growth factor receptor-beta signaling pathway
IRE1-mediated unfolded protein response
negative regulation of MAP kinase activity
negative regulation of insulin receptor signaling pathway
regulation of type I interferon-mediated signaling pathway
JAK-STAT cascade involved in growth hormone signaling pathway
positive regulation of protein tyrosine kinase activity
negative regulation of ERK1 and ERK2 cascade
cell-cell adhesion
regulation of hepatocyte growth factor receptor signaling pathway
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of IRE1-mediated unfolded protein response
negative regulation of PERK-mediated unfolded protein response
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
positive regulation of receptor catabolic process

Function(s)

protein tyrosine phosphatase activity
insulin receptor binding
protein binding
zinc ion binding
enzyme binding
protein kinase binding
receptor tyrosine kinase binding
poly(A) RNA binding
ephrin receptor binding
protein phosphatase 2A binding
cadherin binding involved in cell-cell adhesion