213957

Gene Symbol:

KMT2A TET1

Gene Name:

lysine methyltransferase 2A

tet methylcytosine dioxygenase 1

Gene Aliases:

ALL-1, CXXC7, HRX, HTRX1, MLL, MLL-AF9, MLL/GAS7, MLL1, MLL1A, TET1-MLL, TRX1, WDSTS

CXXC6, LCX, MLL-TET1, TET1-MLL, bA119F7.1

Chromosome Location:

Chr.11: 118436490 - 118526832 on Build GRCh38

Chromosome Location:

Chr.10: 68560360 - 68700794 on Build GRCh38

UniGene ID:

Hs.258855

Hs.258855

Species:

Human

Species Specific ID (Flybase ID):

-

-

siRNA Details

Gene Symbol: KMT2A
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001197104.1	NP_001184033.1	9, 10	4252
	NM_005933.3	NP_005924.2	9, 10	4252
	XM_006718839.3	XP_006718902.2	9, 10	1727
	XM_011542829.2	XP_011541131.1	10, 11	4343
	XM_011542830.2	XP_011541132.1	10, 11	4343
	XM_011542831.2	XP_011541133.1	10, 11	4343
	XM_011542833.2	XP_011541135.1	10, 11	1826
GenBank mRNA	AB209508.1	-	7, 8	1796
	AF232000.1	-	3, 4	323
	AF232001.1	-	3, 4	323
	AF272370.1	-	3, 4	323
	D14540.1	-	9, 10	4252
	L01986.1	-	3, 4	283
	L04284.1	-	9, 10	4229
	L04731.1	-	9, 10	4043
	S78571.1	-		11

Gene Symbol: TET1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
GenBank mRNA	FM165197.1	-		205

More Information

Panther Classification:

Molecular Function -

histone modifying enzyme

Gene Ontology Categories:

Process(es)

DNA methylation
transcription from RNA polymerase II promoter
protein complex assembly
apoptotic process
negative regulation of cell proliferation
visual learning
post-embryonic development
anterior/posterior pattern specification
peptidyl-lysine monomethylation
positive regulation of transporter activity
circadian regulation of gene expression
embryonic hemopoiesis
exploration behavior
response to potassium ion
histone H4-K16 acetylation
histone H3-K4 dimethylation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of short-term neuronal synaptic plasticity
spleen development
homeostasis of number of cells within a tissue
histone H3-K4 methylation
positive regulation of histone H3-K4 methylation
membrane depolarization
definitive hemopoiesis
regulation of histone H3-K14 acetylation
histone H3-K4 trimethylation
regulation of histone H3-K27 acetylation
regulation of histone H3-K9 acetylation
positive regulation of cellular response to drug

Function(s)

core promoter sequence-specific DNA binding
AT DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
zinc ion binding
histone-lysine N-methyltransferase activity
histone methyltransferase activity (H3-K4 specific)
identical protein binding
protein homodimerization activity
transcription regulatory region DNA binding
unmethylated CpG binding
lysine-acetylated histone binding