214732

• Gene Symbol: APEX1
• Gene Name: apurinic/apyrimidinic endodeoxyribonuclease 1
• Gene Aliases: APE, APE1, APEN, APEX, APX, HAP1, REF1
• Chromosome Location: Chr.14: 20455131 - 20457772 on Build GRCh38
• UniGene ID: Hs.73722
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: APEX1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001244249.1	NP_001231178.1	4	625
	NM_001641.3	NP_001632.2	4	630
	NM_080648.2	NP_542379.1	4	564
	NM_080649.2	NP_542380.1	4	574
GenBank mRNA	AK098588.1	-	4	514
	AK291100.1	-	4	539
	BC002338.2	-	4	515	2819505
	BC004979.1	-	4	427	2905681
	BC008145.1	-	4	513	4180383
	BC019291.1	-	4	515	2823545
	BC095428.1	-	5	504	30709297
	BT007236.1	-	3	298
	BT020133.1	-	3	298
	BX161454.1	-	4	464
	D90373.1	-	4	503
	M80261.1	-	4	420
	M81955.1	-	4	508
	S43127.1	-	4	521
	U79268.1	-	4	476
	X59764.1	-	4	507

More Information

Gene Ontology Categories:

Process(es)

telomere maintenance
DNA repair
base-excision repair
base-excision repair, base-free sugar-phosphate removal
DNA recombination
transcription, DNA-templated
regulation of transcription, DNA-templated
aging
negative regulation of smooth muscle cell migration
response to drug
regulation of mRNA stability
cell redox homeostasis
positive regulation of DNA repair
oxidation-reduction process
cellular response to hydrogen peroxide
cellular response to cAMP
cellular response to peptide hormone stimulus
DNA demethylation
RNA phosphodiester bond hydrolysis, endonucleolytic
positive regulation of G1/S transition of mitotic cell cycle
negative regulation of nucleic acid-templated transcription

Function(s)

DNA binding
damaged DNA binding
double-stranded telomeric DNA binding
transcription coactivator activity
transcription corepressor activity
DNA-(apurinic or apyrimidinic site) lyase activity
endonuclease activity
endodeoxyribonuclease activity
RNA-DNA hybrid ribonuclease activity
phosphodiesterase I activity
uracil DNA N-glycosylase activity
protein binding
phosphoric diester hydrolase activity
double-stranded DNA exodeoxyribonuclease activity
double-stranded DNA 3'-5' exodeoxyribonuclease activity
3'-5' exonuclease activity
oxidoreductase activity
site-specific endodeoxyribonuclease activity, specific for altered base
chromatin DNA binding
protein complex binding
poly(A) RNA binding
metal ion binding
NF-kappaB binding