217459

• Gene Symbol: Itch
• Gene Name: itchy E3 ubiquitin protein ligase
• Gene Aliases: -
• Chromosome Location: Chr.3: 150660724 - 150752016 on Build Rnor_6.0
• UniGene ID: Rn.20718
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Itch
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001005887.1	NP_001005887.1	6, 7	654
	XM_008762335.1	XP_008760557.1	8, 9	882
	XM_008762336.1	XP_008760558.1	8, 9	807
	XM_008762337.1	XP_008760559.1	5, 6	559
GenBank mRNA	AY600518.1	-	6, 7	654

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Mouse: NM_008395, NM_001243712, AK048303, AK037940, AK220164, and others.

Panther Classification:

Molecular Function -

ubiquitin-protein ligase

Gene Ontology Categories:

Process(es)

protein polyubiquitination
positive regulation of T cell anergy
ubiquitin-dependent protein catabolic process
protein ubiquitination
negative regulation of NF-kappaB transcription factor activity
protein K29-linked ubiquitination
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of apoptotic process
positive regulation of protein catabolic process
negative regulation of JNK cascade
negative regulation of alpha-beta T cell proliferation
negative regulation of defense response to virus
protein K63-linked ubiquitination
protein K48-linked ubiquitination
regulation of protein deubiquitination

Function(s)

ubiquitin-protein transferase activity
protein binding
ligase activity
ribonucleoprotein complex binding
CXCR chemokine receptor binding
ubiquitin protein ligase activity